摘要
以罗布麻总黄酮为主要原料,制备罗布麻总黄酮泡腾片。通过单因素试验和Box-Behnken响应面试验优化酸碱总用量、酸碱配比(柠檬酸与碳酸氢钠质量比)、PeG 6000用量,并通过测定片重差异、崩解时限、pH、发泡量、脆碎度,对产品进行质量评价。结果表明,罗布麻总黄酮泡腾片最佳制备工艺条件为酸碱总用量38%、酸碱配比1.16︰1、Pe G 6000用量6%,在此工艺条件下制得的罗布麻总黄酮泡腾片感官评分最高(4.61分),且片剂完整,外观良好,酸甜适中,口感柔和可口,反应剧烈,崩解迅速,溶解性能良好,泡腾片的片重差异、硬度、脆碎度、崩解时限、p H、发泡量等指标均符合规定,体外抗氧化活性试验表明罗布麻总黄酮泡腾片具有体外抗氧化活性。
The Apocynum venetum flavonoid effervescent tablets were prepared by using total flavonoids of Apocynum venetum L.as material.The single factor test and Box-Behnken response surface experiment were used to optimize the amount of disintegrant,disintegrant ratio(citric acid and sodium bicarbonate),and PEG 6000 dosage,and to determine the difference in tablet weight,disintegration time limit,pH,foaming amount,friability,and quality evaluation of the product.The results showed that the optimal preparation conditions of Apocynum venetum flavonoid effervescent tablets were as follows:total amount of disintegrant of 38%,disintegrant ratio of 1.16︰1,and PEG 6000 amount of 6%.The effervescent tablet had the highest sensory score of 4.61,and the tablet was complete and had good appearance,moderate sweet and sour,soft and delicious taste,intense reaction,rapid disintegration,and good solubility.The weight difference,hardness,friability,disintegration time limit,p H,foaming amount and other indicators of effervescent tablets complied with the regulations.The antioxidant activity test indicates that the Apocynum venetum flavonoid effervescent tablets had antioxidant activity in vitro.
作者
王慧竹
王禹衡
张兴涛
姜诗宇
陈帅
WANG Huizhu;WANG Yuheng;ZHANG Xingtao;JIANG Shiyu;CHEN Shuai(Chemistry and Pharmaceutical Engineering,Jilin Institute of Chemical Technology,Jilin 132022)
出处
《食品工业》
CAS
北大核心
2020年第8期130-135,共6页
The Food Industry
基金
吉林省教育厅“十三五”科学技术项目(JJKH20190824KJ)
吉林市科技创新发展计划项目(20161215)。
关键词
罗布麻
泡腾片
制备工艺
抗氧化
Apocynum venetum
effervescent tablets
preparation process
antioxidant activity