微生物-肠道-大脑轴在炎症性肠病中的研究

Research of microbiota-gut-brain axis in inflammatory bowel disease

微生物-肠道-大脑轴(microbiota-gut-brain axis,MGBA)在肠道微生物和大脑之间起着双向调节的作用,不仅维持肠道内稳态,也可促进脑病的发生和发展。目前,越来越多的研究表明,MGBA在炎症性肠病(inflammatory bowel disease,IBD)的发病中起着重要的作用,所涉及的途径包括神经信号通路、免疫信号通路及内分泌信号通路。本文就MGBA形成的理论基础及其在IBD应用的研究作一概述,以期为IBD治疗提供新的思路和方法。

Microbiota-gut-brain axis(MGBA)plays a bidirectional regulation role between intestinal microorganisms and brain,not only maintaining intestinal homeostasis,but also promoting the occurrence and development of encephalopathy.At present,more and more studies have shown that MGBA plays an important role in the pathogenesis of inflammatory bowel disease(IBD),involving pathways including neural signaling pathways,immune signaling pathways and endocrine signaling pathways.In this paper,the theoretical basis of MGBA formation and its application in IBD were reviewed in order to provide new ideas and methods for the treatment of IBD.