碱性鞘磷脂酶抑制炎症性肠病的研究

Research of alkaline sphingomyelinase in inhibiting inflammatory bowel disease

碱性鞘磷脂酶(alkaline sphingomyelinase,alk-SMase)最初作为肠道中水解鞘磷脂(sphingomyelin,SM)的关键酶被人们所认知。随着SM代谢通路在细胞增殖和凋亡中的作用被认识,人们开始探索alk-SMase在肠道中的潜在功能。近年来,alk-SMase通过参与磷脂代谢在结肠炎症和肿瘤中的作用逐渐被发现,证实了它是肠道中的一个保护因子。本文将重点对alk-SMase通过参与磷脂分子代谢抵抗炎症性肠病(inflammatory bowel disease,IBD)的研究作一概述。

Alkaline sphingomyelinase(alk-SMase)is initially known as a key enzyme for hydrolyzing sphingomyelin(SM)in the intestinal tract.People pay attention to this enzyme because of the function of the SM metabolic pathway in cell proliferation and apoptosis.In recent years,alk-SMase has been gradually found to play a role in colitis and colonic tumorigenesis through its involvement in phospholipid metabolism.The enzyme has been proved to be a protective factor in intestinal tract.This article aimed to summarize the research of alk-SMase on inhibiting intestinal inflammatory bowel disease(IBD)through its involvement in phospholipid metabolism.