他汀类药物在炎症性肠病中的作用

Effect of statins in inflammatory bowel disease

他汀类药物临床上主要用于降血脂及心血管事件的防治,但由于其还具有抗炎、抗氧化及细胞保护功能等多效性作用近年来逐渐受到重视。鉴于炎症性肠病(inflammatory bowel disease,IBD)传统治疗及现有生物制剂疗效及不良反应,他汀类药物在IBD中辅助治疗作用受到关注,因此本文拟对他汀类药物在IBD中的研究作一概述,为临床应用提供理论依据。

Statins are mainly used for the prevention and treatment of hypolipidemic and cardiovascular events,but in recent years,they have received increasing attention due to their pleiotropic effects such as anti-inflammatory,antioxidation and cytoprotective functions.In view of the traditional treatment of inflammatory bowel disease(IBD)and the efficacy and adverse reactions of existing biological agents,the role of statins in the adjuvant treatment of IBD has attracted attention.Therefore,this paper reviewed the progress of statins in IBD,so as to provide theoretical basis for clinical application.