吲哚胺2,3-双加氧酶1对幽门螺旋杆菌免疫调节的研究进展

Advances in immune regulation of Helicobacter pylori by indoleamine 2,3-dioxygenase1

幽门螺旋杆菌(Helicobacter pylori,H.pylori)是一种广泛黏附定植于胃黏膜的革兰阴性杆菌,流行病学研究显示,H.pylori感染是慢性胃炎的主要病因,长期停留于胃内可能导致慢性浅表性胃炎、慢性萎缩性胃炎、肠化生、异型增生和最终胃癌的发生;吲哚胺2,3-双加氧酶1(indoleamine 2,3-dioxygenase1,IDO1)是一种免疫调节酶,可在炎症过程中激活,诱导免疫耐受而有助于细菌长期生存;本文对胃黏膜中IDO1表达对H.pylori及H.pylori感染胃黏膜疾病发展的免疫调节作一概述。

Helicobacter pylori(H.pylori)is a Gram-negative bacillus that is widely adhered to the gastric mucosa.Epidemiological studies have shown that H.pylori infection is the main cause of chronic gastritis.Prolonged stay in the stomach may lead to chronic superficial gastritis,chronic atrophic gastritis,intestinal metaplasia,dysplasia,and eventual gastric cancer occur;indoleamine 2,3-dioxygenase1(IDO1)is an immunomodulatory enzyme that can be activated during inflammation and induces immune tolerance and contributes to the long-term existence of bacteria.This article reviewed the advances in immune regulation of H.pylori and the development of H.pylori-infected gastric mucosal disease by IDO1.