诺丽酒降血脂功能研究

Study on the hypolipidemic function of Noni wine

通过建立高血脂症肥胖小鼠模型,将雄性小鼠分为空白对照组、低脂肪组和高脂肪组,与诺丽酒低、中、高剂量组,灌胃小鼠90 d,测定睾脂率、肾脂率和体脂率以及小鼠血清中总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇含量和呼吸交换率。结果表明,中、高剂量诺丽酒组可有效降低肥胖小鼠体重或体增量,其睾脂率、肾脂率或体脂率降低,甘油三酯、胆固醇或低密度脂蛋白含量显著降低,高密度脂蛋白含量提高,且能促进小鼠对脂肪消化,提高产热量和活动量,表明诺丽酒具有辅助降血脂的作用。

Established a mouse model of hyperlipidemia.The male mice were divided into blank control group,low fat group and high fat group,and the low dose,medium dose,high dose of Noni wine.Serum concentrations of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),respiratory exchange ratio(RER),were measured after 90 days of feeding.The results showed that medium dose and high dose can effectively reduce the body weight or body weight gain of the obese mice,and the testis fat rate,renal fat rate or body fat rate decreased.The serum TC content,TG content and LDL-C in hyperlipidemia mice were significantly reduced,and the HDL-C was increased.Noni wine can promote fat digestion,increase calorie production and activity of mice,which indicated that Noni wine had hypolipidemic effect.