健体固本合剂治疗肺脾气虚型儿童反复呼吸道感染的疗效及对免疫功能的影响

Effect of Jianti Guben Mixture on respiratory tract infection in children with lung-spleen Qi deficiency and its effect on immune function

目的观察健体固本合剂治疗肺脾气虚型儿童反复呼吸道感染的疗效,并探讨其对患儿免疫功能的影响。方法选择2018年1月至2019年5月在西安高新医院儿科就诊的90例肺脾气虚型反复呼吸道感染患儿作为研究对象。采用随机数表法分为观察组和对照组各45例。对照组采用利巴韦林颗粒治疗,观察组在此基础上联合健体固本合剂治疗。4周为一个疗程,治疗3个月后比较两组患儿的治疗效果和症状消失时间,同时比较两组患儿治疗前后的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平,并统计不良反应情况。结果观察组患儿的治疗总有效率为95.56%,明显高于对照组的82.00%,差异有统计学意义(P<0.05);治疗后,观察组患儿的咳嗽、发热、喘息等症状消失时间[(5.12±1.02)d、(3.02±0.37)d、(3.87±0.89)d]明显短于对照组[(6.89±0.78)d、(4.88±0.46)d、(5.12±0.92)d],差异均有统计学意义(P<0.05),但两组患儿的肺内啰音消失时间比较差异无统计学意义(P>0.05);与治疗前比较,两组患儿治疗后的IgA、IgG、IgM表达水平均明显升高,且观察组[(1.58±0.32)g/L、(13.12±2.45)g/L、(1.89±0.42)g/L]明显高于对照组[(1.25±0.33)g/L、(10.78±1.85)g/L、(1.42±0.32)g/L],差异均有统计学意义(P<0.05);两组患儿的不良反应比较差异无统计学意义(P>0.05)。结论健体固本合剂治疗肺脾气虚型儿童反复呼吸道感染可提高患儿免疫功能,促进临床症状消失,临床治疗效果较好,安全可靠。

Objective To observe the therapeutic effect of Jianti Guben Mixture on repeated respiratory tract infections in children with lung-spleen Qi deficiency,and explore its effect on the immune function of children.Methods Ninety children of lung and spleen Qi deficiency with recurrent respiratory tract infection who were treated in Department of Pediatrics,Xi'an High-tech Hospital from January 2018 to May 2019 were selected as the research objects.Using random number table method,the patients were divided into observation group and control group,each with 45 patients.The control group was treated with ribavirin granules,and the observation group was treated with Jianti Guben mixture on this basis,with 4 weeks as a course of treatment.The treatment effect and the time of symptom disappearance were compared after 3 courses of treatment.The levels of immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)before and after treatment were compared.In comparison,the adverse reactions are observed.Results The total effective rate of treatment in the observation group was 95.56%,which was significantly higher than 82.00%in the control group(P<0.05).After treatment,the time of cough,fever,wheezing,and other symptoms disappearance in the observation group were(5.12±1.02)d,(3.02±0.37)d,(3.87±0.89)d,respectively,significantly shorter than(6.89±0.78)d,(4.88±0.46)d,(5.12±0.92)d in the control group(P<0.05).There was no statistically significant difference in the disappearance time of intrapulmonary rales in the two groups of children(P>0.05).Compared with before treatment,the levels of IgA,IgG,and IgM in children's immune function were elevated,and the levels in the observation group were(1.58±0.32)g/L,(13.12±2.45)g/L,(1.89±0.42)g/L,which were significantly higher than(1.25±0.33)g/L,(10.78±1.85)g/L,(1.42±0.32)g/L in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups of children(P>0.05).Conclusion Jianti Guben Mixture for the treatment of recurrent respiratory tract infections in children of lung and spleen Qi deficiency can improve the immune function of children and promote the disappearance of clinical symptoms,with reliable clinical treatment and good safety,which is worthy of clinical promotion.