Toll样受体4信号传导通路与支气管哮喘的关系

Relationship between the toll-like receptor 4 signaling pathway and bronchial asthma

支气管哮喘是常见的、反复发作的气道免疫炎症性疾病,其特征表现为气道高反应,往往由各种因素所诱发。Toll样受体(TLR)属于固有免疫病原模式识别受体,TLR信号传导通路的激活会加重气道炎症及气道高反应性,引起炎症因子释放,抑制TLR4信号通路可有效降低相关炎性细胞因子的表达。该文对TLR4与哮喘的关系及哮喘的靶向治疗进行综述。

Bronchial asthma is a common recurrent immune inflammatory disease of the airway,which is characterized with airway hyperresponsiveness and constantly induced by various factors.Toll-like receptors(TLR)belong to a category of innate immune pathogen pattern recognition receptors.The activation of TLR signaling pathway will aggravate the airway inflammation and hyperresponsiveness,cause the release of inflammatory cytokines and inhibit the TLR4 signaling pathway,which can effectively down-regulate the expression of related inflammatory cytokines.In this article,the relationship between TLR4 and asthma and its targeted therapies was reviewed.