APOE基因多态性与精神分裂症及患者认知功能的关联性研究

Association between APOE polymorphism with the onset of schizophrenia and cognitive function

目的探讨载脂蛋白E(APOE)基因多态性与精神分裂症及患者认知功能的关系。方法采用PCR-DNA测序对200例精神分裂症患者(患者组)和167名正常对照者(对照组)的APOE基因多态性进行检测,采用霍普金斯词语学习测验、范畴流畅性测验、Corsi组块测验、连线测验、威斯康星卡片分类测验和持续注意力相同匹配测验评定精神分裂症患者的认知功能。结果2组APOE基因型频率和等位基因分布频率差异均无统计学意义(P均>0.05)。在200例精神分裂症患者中,APOEε3等位基因携带者CPT-IP中3位数D值得分高于APOEε3等位基因非携带者(P<0.05)。结论APOE基因多态性可能与精神分裂症发病无关,但APOEε3等位基因可能与精神分裂症患者注意功能有关。

Objective To explore the association between the polymorphism of apolipoprotein E(APOE)with the onset of schizophrenia and cognitive function.Methods The polymorphism of APOE in 200 schizophrenia patients and 167 healthy controls was genotyped by using PCR-DNA sequencing.The cognitive function of all schizophrenia patients was assessed by using Hopkin Verbal Learning Test-Revision,Category Fluency Test,Wisconsin Card Sorting Test,Corsi Block Tapping Test,Connections Test and Continuous Performance Test.Results The genotype distribution and allelic frequency of APOE did not significantly differ between the schizophrenia and control groups(both P>0.05).The 3-digit D score in CPT-IP inε3 allele carriers with APOEε3+genotypes was significantly higher than that in those with APOEε3-genotypes(P<0.05).Conclusion APOE polymorphism is not associated with the incidence of schizophrenia.However,APOEε3+allele may be correlated with the attention function of patients with schizophrenia.