PCOS患者血清中人组织激肽释放酶结合蛋白水平及其与肥胖的相关性分析

Correlation analysis between the serum kallistatin level and obesity in patients with PCOS

目的探讨多囊卵巢综合征(PCOS)患者血清中人组织激肽释放酶结合蛋白(KS)水平及其与肥胖的相关性。方法选择42例PCOS患者作为PCOS组、46例月经正常的育龄期妇女作为对照组,比较2组的血清KS水平及其与胆固醇等脂代谢指标的相关性。结果PCOS组BMI、总胆固醇、甘油三酯、LDL-C、血清KS水平均高于对照组(P<0.05)。PCOS组中血清KS水平与肥胖代谢相关生化指标均呈正相关(P均<0.05)。结论血清KS水平与脂代谢相关指标密切相关,提示代谢紊乱与KS共同促进PCOS的发生。

Objective To evaluate the serum kallistatin(KS)level in patients with polycystic ovary syndrome(PCOS)and investigate its correlation with obesity.Method Forty-two patients with PCOS(PCOS group)and 46 health controls(control group)were enrolled in this study.The serum KS level was statistically compared between two groups,and its correlation with alternative lipid metabolism-related biomarkers was analyzed.Results In the PCOS group,the body mass index(BMI),total cholesterol,triglyceride,LDL-C and serum KS level were significantly higher compared with those in the control group(all P<0.05).In the PCOS group,the serum KS level was positively correlated with lipid metabolism-related biomarkers(all P<0.05).Conclusion The serum KS level is intimately associated with lipid metabolism-related biomarkers,prompting that KS and lipid metabolism disorder collectively contribute to the incidence of PCOS.