妊娠期糖尿病患者凝血指标差异性分析及其与不良妊娠的关系

Differential Analysis of Coagulation Parameters in Gestational Diabetes Mellitus and Its Relationship with Adverse Pregnancy

目的探讨妊娠期糖尿病患者凝血指标的差异性及其与不良妊娠的关系。方法回顾分析2017年1月-2019年6月河南科技大学第一附属医院妇产科就诊的GDM患者(118例)及同期体检健康的118例产妇资料。将GDM患者纳入病例组,健康产妇纳入对照组。收集两组患者的一般资料,检测凝血指标。结果病例组体质量、妊娠期增重高于对照组(P<0.05);病例组FIB、DD水平高于对照组(P<0.05),APTT水平低于对照组(P<0.05),差异均有统计学意义。病例组不良妊娠率高于对照组(P<0.05),APTT、FIB、DD、体质量、妊娠期增重与不良妊娠呈正相关(P<0.05)。结论妊娠期糖尿病患者更易出现高凝的异常状态,其凝血功能紊乱促进不良妊娠的发生,建议积极控制体重及血糖的同时,尽早干预凝血功能变化,保障母婴健康。

Objective To investigate the difference of coagulation parameters in gestational diabetes mellitus and its relationship with adverse pregnancy.Methods 118 GDM women and 118 healthy women in First Affiliated Hospital of Henan University of Science and Technology from January 2017 to June 2019 were enrolled,and the indicators were compared between groups.Results The body weight,weight gain during pregnancy,FIB and DD levels in the case group were higher than those in the control group(P<0.05).The adverse pregnancy rate and APTT level in the case group were higher than those in the control group(P<0.05).APTT,FIB,DD,body mass and weight gain during pregnancy were positively correlated(P<0.05).Conclusion The coagulation disorder and adverse pregnancy outcomes of gestational diabetes mellitus patients are more obvious,so early treatment is recommended.