黄立中教授治疗中晚期肺癌的中药用药规律

Medication Rule of Chinese Materia Medica by Professor HUANG Lizhong for Treatment of Middle and Advanced Lung Cancer

目的采用数据挖掘方法研究黄立中教授治疗中晚期肺癌的中药用药规律。方法选取黄立中教授门诊治疗的中晚期肺癌患者100例,共500诊次的处方,采用Aprior算法,对其进行关联规则分析,探讨黄立中教授治疗中晚期肺癌的中药用药规律,并与黄立中教授进行交流、可信度分析与验证。结果500诊次的处方中共涉及145味中药,药物总频次8543。词频最高的前三位药物依次是法半夏、桑白皮、北沙参。中药类别中使用频次最高的是化痰散结药、益气润肺药、肃降肺气药、止咳平喘药,体现了黄教授论治肺癌时注重通补结合,攻补兼施。Apriori计算结果显示:二阶关联支持度最高的是法半夏和桑白皮配伍;三阶关联支持度最高的是北沙参、桑白皮和法半夏配伍;四阶关联支持度最高的是法半夏、浙贝母、北沙参和桑白皮配伍。可信度验证:数据挖掘结果可信度约为88%。结论黄立中教授治疗中晚期肺癌从正气亏虚,痰毒瘀互结的病机着手,处方遣药首护元气,常用补气养阴,化痰散结,泻肺平喘及对症诸法联合治疗,有效提高患者生活质量,延长生命周期。

Objective To study medication rule of Chinese materia medica by Professor HUANG Lizhong for treatment of middle and advanced lung cancer by data mining.Methods A total of 100 patients with middle and advanced lung cancer treated by Professor HUANG Lizhong in the outpatient department were selected,with a total of 500 prescriptions.Apriori algorithm was used for association rules analysis to explore were analyzed to explore medication rule of Chinese materia medica by Professor HUANG Lizhong for treatment of middle and advanced lung cancer,and also had communicate with Professor HUANG Lizhong for analysis and verification of credibility.Results A total of 145 Chinese materia medica were used in the prescription of 500 consultations,with a frequency of 8543.The top 3 frequently used herbs were Rhizoma Pinelliae Preparatum,Cortex Mori and Radix Glehniae.Among the categories of Chinese materia medica,the most frequently used were phlegm-relieving and mass-removing medicines,followed by benefiting Qi and moistening lung medicines,purification and descending lung Qi medicines,cough-stopping and asthma-relieving medicines.It embodies Professor HUANG's emphasis on the combination of unblocking and supplementation,attacking and supplementation in the treatment of lung cancer.Apriori calculation results showed that the highest support of the second-order association was the compatibility of Rhizoma Pinelliae Preparatum and Cortex Mori;the highest support of the third-order association was the compatibility of Radix Glehniae,Cortex Mori and Rhizoma Pinelliae Preparatum;the highest support of the fourth-order association was the compatibility of Rhizoma Pinelliae Preparatum,Bulbus Fritillariae Thunbergii,Radix Glehniae and Cortex Mori.For credibility verification,the credibility of data mining results was about 88%.Conclusion Professor HUANG Lizhong's treatment of middle and advanced lung cancer starts with the pathogenesis of deficiency of positive Qi,intermingling of phlegm,toxin and blood stasis.Prescription and medication were used to protect primordial Qi,and they are commonly used to invigorate Qi and nourish Yin,resolve phlegm and dispel stagnation,purging lung and anti-asthma and symptomatic combined treatment,which can effectively improve the quality of life of patients and prolong survival time.