卵巢组织冻存和移植技术在宫颈癌患者内分泌功能保存中的进展

Advances in preservation of endocrine function with ovarian tissue cryopreservation and transplantation in cervical cancer

宫颈癌发病率居妇科恶性肿瘤首位。近年来,随着筛查体系的逐步完善及诊治水平的不断提高,宫颈癌5年生存率显著提高,但手术、放射治疗、化学药物治疗使部分年轻患者的卵巢功能受损,造成医源性早发性卵巢功能不全,导致患者更年期提前,生活质量也随之下降。自体卵巢组织冻存和移植作为一种新兴的生育力保存技术发展迅速,且在年轻宫颈癌患者卵巢内分泌功能保存方面展现出巨大潜力。

The incidence of cervical cancer ranks the first among the gynecological malignant tumors.Given the implementation of widespread cervical cancer screening and the improvement of clinical treatment,the cervical cancer mortality has decreased substantially.However,surgery,radiotherapy,and chemotherapy may impair the ovarian function,resulting in premature ovarian insufficiency and premature climacteric,which has reduced the quality of life in young patients.As a new fertility preservation technology,autologous ovarian tissue cryopreservation and transplantation is developing rapidly and showing great potentiality in preserving ovarian endocrine function of young cervical cancer patients.