劳拉西泮联合阿托伐他汀治疗老年冠心病合并焦虑患者的临床效果

Clinical effect of lorazepam combined with atorvastatin in the treatment of elderly patients with coronary heart disease complicated with anxiety

目的探讨劳拉西泮联合阿托伐他汀治疗老年冠心病合并焦虑患者的临床效果。方法纳入我院收治的老年冠心病合并焦虑患者160例,按照随机数字法将其分为对照组和劳拉西泮组,各80例。对照组在常规治疗的基础上服用阿托伐他汀,劳拉西泮组在对照组的基础上服用劳拉西泮。比较两组的临床疗效、心率变异指标及心血管不良事件发生情况。结果劳拉西泮组的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组SDNN和PNN50均明显增加,且劳拉西泮组高于对照组(P<0.05)。对照组心血管不良事件总发生率明显高于劳拉西泮组(P<0.05)。结论劳拉西泮联合阿托伐他汀治疗老年冠心病合并焦虑患者的效果较好,能够有效改善患者的心率变异情况,降低心血管不良事件发生率。

Objective To explore the clinical effect of lorazepam combined with atorvastatin in the treatment of elderly patients with coronary heart disease complicated with anxiety.Methods A total of 160 elderly patients with coronary heart disease complicated with anxiety admitted in our hospital were included and divided into control group and lorazepam group according to random number table method,with 80 cases in each group.The control group took atorvastatin on the basis of conventional treatment,and the lorazepam group took lorazepam on the basis of the control group.The clinical effects,heart rate variability indexes and occurrence of cardiovascular adverse events of the two groups were compared.Results The total effective rate of treatment of the lorazepam group was significantly higher than that of the control group(P<0.05).After treatment,SDNN and PNN50 significantly increased in both groups,and those in the lorazepam group were higher than the control group(P<0.05).The total incidence of cardiovascular adverse events in the control group was significantly higher than that in the lorazepam group(P<0.05).Conclusion Lorazepam combined with atorvastatin in the treatment of elderly patients with coronary heart disease complicated with anxiety has a better effect,which can effectively improve the patients’heart rate variation and reduce the incidence of cardiovascular adverse events.