支气管哮喘患者症状严重程度与气道炎症的关系探讨

Relationship between symptom severity and airway inflammation in patients with bronchial asthma

目的探讨支气管哮喘患者症状严重程度与气道炎症的关系。方法我院收治的80例支气管哮喘患者为试验组(急性发作期38例和缓解期42例),根据哮喘症状评分分为轻度25例、中度28例和重度27例;同期收治的80例肺部病变者(非哮喘组)和健康体检者80例(对照组)。诱导痰上清液检测中性粒细胞、嗜酸性细胞、白细胞介素8(IL-8)、嗜酸粒细胞阳离子蛋白(ECP)及中性粒细胞髓过氧化物酶(MPO)水平,比较对照组、非哮喘组、试验组及试验组不同严重程度患者各气道炎症指标水平,分析支气管哮喘症状严重程度与气道炎症的关系。结果试验组中性粒细胞、嗜酸性细胞、IL-8、ECP、MPO高于非哮喘组和对照组;试验组重度患者中性粒细胞、嗜酸性细胞、IL-8、ECP、MPO高于轻、中度患者;急性发作期患者中性粒细胞、嗜酸性细胞、IL-8、ECP、MPO高于缓解期患者(P<0.05)。中性粒细胞、嗜酸性细胞、IL-8、ECP、MPO与哮喘症状评分呈正相关(P<0.05)。结论支气管哮喘患者症状的严重程度与气道炎症有密切的关系,加强对气道炎症指标的监测,可为疾病的诊治提供参考。

Objective To investigate the relationship between symptom severity and airway inflammation in bronchial asthma patients.Methods The 80 patients with bronchial asthma admitted to our hospital were in the experimental group(38 patients in the acute stage and 42 in the remission stage).According to the asthma symptom scores,they were divided into 25 patients with mild asthma,28 patients with moderate asthma and 27 patients with severe asthma.In the same period,80 cases of pulmonary lesions(non-asthma group)and 80 cases of healthy physical examination(control group)were admitted.Induced sputum supernatant on neutrophil and eosinophilic cells,interleukin 8(IL-8),acidophilic granulocyte cationic protein(ECP)and neutrophil myeloperoxidase(MPO)levels,compared the control group,the patients with different severity of asthma group,experimental group and test group each level of airway inflammation index,analysis of the relationship between bronchial asthma symptom severity and airway inflammation.Results Neutrophils,eosinophilic cells,IL-8,ECP and MPO in the experimental group were higher than those in the non-asthma group and the control group.Neutrophils,eosinophilic cells,IL-8,ECP,and MPO were higher in severe patients than in mild and moderate patients.Neutrophils,eosinophilic cells,IL-8,ECP and MPO were higher in the acute stage than in the remission stage(P<0.05).Neutrophils,eosinophilic cells,IL-8,ECP and MPO were positively correlated with asthma symptom score(P<0.05).Conclusion The severity of symptoms in patients with bronchial asthma is closely related to airway inflammation.Strengthening the monitoring of airway inflammation indicators can provide reference for the diagnosis and treatment of the disease.