分析产前超声诊断孤立性侧脑室不对称妊娠结局

Analysis of pregnancy outcome of prenatal ultrasonic diagnosed solitary lateral ventricular asymmetry

目的观察产前超声诊断胎儿孤立性侧脑室不对称的妊娠结局。方法回顾性分析191胎产前超声诊断孤立性侧脑室不对称胎儿的影像学资料及妊娠结局,出生后电话随访6~12个月,并以婴儿神经发育评估法评估婴幼儿反应及行为等有无异常。结果191胎中,98胎为单纯不对称,占51.31%(98/191);93胎为单侧脑室增宽,占48.69%(93/191)。随孕周增加,130胎(130/191,68.06%)侧脑室宽度恢复正常,58胎(58/191,30.37%)未见明显变化,3胎(3/191,1.57%)进展。2例接受脐血穿刺染色体核型检查,1胎为18三体,核型为47,XN,+18,另1胎染色体核型正常。189胎正常娩出,2胎引产,其中1胎染色体核型异常,1胎单侧侧脑室进展性增宽,高度疑诊双侧脑半球发育不良。结论孤立性侧脑室不对称对胎儿生长及发育无明显影响,其预后与侧脑室宽度变化情况有关,应密切随访观察。

Objective To analyze the pregnancy outcome of prenatal ultrasonic diagnosed fetal solitary lateral ventricular asymmetry.Methods Imaging data and pregnancy outcome of 191 fetuses with prenatal ultrasonic diagnosed solitary lateral ventricle asymmetry were retrospectively analyzed.The infants were followed up for 6-12 months after birth,and infant neurodevelopmental assessment was used to assess whether there were abnormal reactions and behaviors.Results Among 191 fetuses,98 were found with asymmetric(98/191,51.31%),while 93 were found with unilateral ventricular broadening(93/191,48.69%).With the development of pregnancy,the width of lateral ventricle became normal in 130 fetuses(130/191,68.06%),remained as former in 58 fetuses(58/191,30.37%)but further expanded in 3 fetuses(3/191,1.57%).In addition,2 cases underwent umbilical cord blood puncture chromosome karyotype examination,1 was trisomy 18,the karyotype was 47,XN,+18,and the other was normal.Normal delivery achieved in 189 fetuses,while 2 received labor induction,1 with chromosomal karyotype abnormality and the other was considered as unilateral lateral ventricular progressive broadening combined with prenatal MRI suspected bilateral cerebral hemisphere dysplasia.Conclusion Fetal solitary unilateral unilateral ventricular asymmetry has no obvious impact on fetal growth and development fetuses.The pregnancy outcome and prognosis mainly depends on the intrauterine progress of lateral ventricular width,which need to be closely monitored and followed-up.