主动脉夹层发病机制研究进展

Advances in the pathogenesis of aortic dissection

主动脉夹层发病凶险,死亡率高,发病机制尚不明确,给患者个人、家庭和社会带来沉重的负担。提高诊治效率,明确发病机制是主动脉夹层研究的热点。近年来,通过生物信息学技术寻找主动脉夹层的诊断标志物,探索炎症过程、细胞外基质降解、弹力纤维断裂、平滑肌细胞表型转化与主动脉夹层发病机制间的联系是该领域的热门话题。本文通过分析国内外相关文献,总结近年来主动脉夹层发病机制的研究进展,希望找到主动脉夹层发病机制中的关键分子,并为疾病的预防、诊断和治疗提供一定的参考。

Aortic dissection is a catastrophic emergency with a high mortality rate,and its full pathogenesis remains unknown to researchers,which brings a heavy burden to the individuals,society and family because of its poor prognosis.Improving the efficiency of its diagnosis and treatment and defining the pathogenic mechanism clearly is a research hotspot.Recently,utilizing bioinformatics to find diagnostic biomarker of aortic dissection has attracted the attention of many researchers.Besides,exploring the relationship between pathogenic mechanism and inflammatory process,extracellular matrix degradation,elastic fiber fracture and the phenotypic transformation of vascular smooth muscle cells is also a hot topic.We summarize recent progress made in the pathogenesis of aortic dissection.We hope to identify key molecules driving aortic dissection and provide reliable reference for the diagnosis,medical treatment and prevention of aortic dissection.