TyG指数与稳定性冠心病及冠状动脉钙化斑块负荷的相关性

The correlation between TyG index and stable coronary artery disease and coronary artery calcified plaque burden

目的探讨三酰甘油葡萄糖(TyG)指数与冠状动脉疾病(CAD)及冠状动脉钙化斑块负荷的相关性。方法连续收集2015年9月—2017年6月承德医学院附属医院住院的符合纳入标准的疑似稳定性CAD的患者620例。根据冠状动脉CT血管造影(CCTA)结果将所有研究对象分为CAD组(n=449)和non-CAD组(n=171)。收集所有患者的临床资料,检查冠状动脉钙化(CAC)情况并进行冠状动脉钙化评分(CACS)。建立多因素二元Logistic回归模型,分析CAD和CAC的危险因素。结果高TyG指数组CAD、2型糖尿病、血脂异常和CAC比例均较低TyG指数组高(均P<0.05)。TyG指数与CACS呈正相关,与CAD危险因素心表面脂肪组织体积、心外膜脂肪组织体积、体质量指数等呈正相关,而与年龄和血清镁水平呈负相关(均P<0.05)。除经典危险因素外,TyG指数≥8.23也是CAD和CAC的独立危险因素(P<0.05)。结论高TyG指数与冠状动脉粥样硬化斑块负荷及CAD患病相关,TyG指数升高是CAD和CAC的独立危险因素。

Objective To explore the correlation between triglyceride glucose(TyG)index with coronary artery disease(CAD)and coronary artery calcified plaque burden.Methods A total of 620 inpatients with suspected stable CAD were consecutively enrolled from September 2015 to June 2017 in the Affiliated Hospital of Chengde Medical College.Patients were divided into CAD group(n=449)and non-CAD group(n=171)according to coronary computed tomographic angiography(CCTA)results.The clinical data and coronary artery calcification score(CACS)of all patients were collected.A binary Logistic regression model was established on the risk factors of CAD and CAC.Results The prevalence of CAD,type 2 diabetes,dyslipidemia and CAC were higher in the high TyG index group than those in the low TyG index group(all P<0.05).TyG index was positively correlated with CACS and classical risk factors of CAD including epicardial adipose tissue enlargement,pericardial adipose tissue enlargement and body mass index,while negatively correlated with serum magnesium(all P<0.05).Conclusion High TyG index is associated with coronary atherosclerosis plaque burden and CAD.The increased TyG index is an independent risk factor for CAD and CAC.