儿童紫癜性肾炎的免疫机制研究

Study on the Immune Mechanism of Children's Purpuric Nephritis

紫癜性肾炎(HSPN)是继发于过敏性紫癜(HSP)的肾脏疾病,大部分HSPN患儿预后良好,但少部分患儿可出现肾功能不全,甚至发展为终末期肾病,影响其生存质量。HSPN病因复杂,诱因可能有感染、药物、食物过敏等,其确切发病机制至今尚未完全清楚,明确其发病机制对指导治疗改善患儿预后有着重要意义。本文主要从体液免疫、细胞免疫等方面对紫癜性肾炎的免疫机制进行综述,旨在进一步了解其发病机制,为该病的治疗提供新的思路。

Purpuric nephritis(HSPN)is a kidney disease secondary to Henoch-Schonlein purpura(HSP).Most children with HSPN have a good prognosis,but a small number of children may develop renal insufficiency and even develop end-stage renal disease,which affects their quality of life.The etiology of HSPN is complicated,and the triggers may include infections,drugs,food allergies,etc.The exact pathogenesis of HSPN has not yet been fully understood.It is important to guide treatment to improve the prognosis of children.This article mainly reviews the immune mechanism of purpuric nephritis from the aspects of humoral immunity and cellular immunity,aiming to further understand its pathogenesis and provide new ideas for the treatment of the disease.