脑梗死患者血清腱糖蛋白-C与梗死体积的关系

The Relationship Between Serum Tenascin-C and Infarct Volume in Patients with Cerebral Infarction

目的探讨血清腱糖蛋白-C(TNC)与急性脑梗死患者梗死体积及神经功能缺损程度的相关性。方法选择2016年7~10月我院神经内科住院的38例急性脑梗死患者作为实验组,另外选取同期健康体检者28名作为健康对照组。根据脑梗死体积将实验组分为小、中、大梗死组,根据神经功能缺损程度将实验组分为轻、中、重度损伤组,比较实验组和健康对照组年龄、性别、高血压、糖尿病、吸烟构成比、饮酒构成比、平均收缩压(SBP)、平均舒张压(DBP)、血清低密度脂蛋白浓度、发病第1、5天血清TNC浓度;比较不同梗死体积、神经功能损伤程度患者的血清TNC浓度。结果实验组高血压、糖尿病、吸烟构成比、SBP、DBP均高于健康对照组,差异有统计学意义(P<0.05);两组性别、饮酒构成比、年龄、血清低密度脂蛋白水平比较,差异无统计学意义(P>0.05);发病第1、5天,实验组血清TNC浓度高于健康对照组,差异有统计学意义(P<0.05);发病第1天,小、中、大梗死组及轻、中、重度损伤组血清TNC浓度均高于健康对照组,且小、中、大梗死组血清TNC浓度比较,差异有统计学意义(P<0.05);轻、中、重度损伤组血清TNC浓度比较,差异有统计学意义(P<0.05)。结论血清TNC水平与缺血性卒中密切相关,可反映急性脑梗死梗死灶的大小及患者神经功能缺损的严重程度。

Objective To investigate the correlation between serum tenascin-C(TNC)and infarct volume and neurological deficit in patients with acute cerebral infarction.Methods 38 patients with acute cerebral infarction who were hospitalized in the Department of Neurology of our hospital from July to October 2016 were selected as the experimental group,and 28 healthy subjects were selected as the healthy control group.According to the cerebral infarction volume,the experimental groups were divided into small,medium,and large infarction groups,and the experimental groups were divided into mild,moderate,and severe injury groups according to the degree of neurological impairment.Compare the experimental group and the healthy control group in terms of age,gender,hypertension,and diabetes,smoking composition ratio,drinking composition ratio,mean systolic blood pressure(SBP),mean diastolic blood pressure(DBP),serum low-density lipoprotein concentration,serum TNC concentration on the first and fifth days of onset;compare patients with different infarct volume and neurological impairment the serum TNC concentration.Results The composition ratio of hypertension,diabetes,smoking,SBP,and DBP in the experimental group were higher than those in the healthy control group,the difference was statistically significant(P<0.05);comparison of gender,drinking composition,age,and serum low-density lipoprotein levels between the two groups,the difference was not statistically significant(P>0.05);the serum TNC concentration of the experimental group was higher than that of the healthy control group on the first and fifth days of onset,the difference was statistically significant(P<0.05);on the first day of onset,small,medium and large The serum TNC concentration of the infarct group and the mild,moderate,and severe injury group was higher than that of the healthy control group,the difference in the serum TNC concentration of the small,medium,and large infarction group was statistically significant(P<0.05);light,moderate,and severe injury there was a statistically significant difference in serum TNC concentration between the groups(P<0.05).Conclusion Serum TNC level is closely related to ischemic stroke,and could reflect the size of acute cerebral infarction and the severity of the patient's neurological deficit.