北京京煤集团总医院健康体检者血清AFP检测结果分析

Analysis of Serum AFP Test Results of Healthy Physical Examination in Beijing Jingmei Group General Hospital

目的通过对北京市区体检人群血清甲胎蛋白(AFP)的结果回顾性分析,探讨血清AFP含量在健康人群中的参考范围,以及与性别、年龄之间的关系。方法选取2019年2~10月,来自北京京煤集团总医院体检中心健康体检人群,共计10124例,采用化学发光免疫分析法检测血清AFP含量,建立参考范围,分别比较不同性别、不同年龄段之间血清AFP含量的差异。结果本研究检测的正常人群的AFP参考范围为0~7.10 ng/ml,男性与女性AFP的平均含量存在显著性差异,不同年龄段的男性之间和女性之间也存在差异性,在20~69岁年龄段健康男性、女性和总体人群的血清AFP平均含量都随年龄的增加而增加,70岁以上AFP水平有所降低,阳性率随年龄的增加呈现先上升后下降的趋势。结论总体AFP参考范围0~7.10 ng/ml适合本实验室筛查,健康人群中血清AFP的含量与性别、年龄相关,AFP阳性率随年龄的增加呈现先上升后下降的趋势。

Objective To retrospectively analyze the results of serum alpha-fetoprotein(AFP)in the physical examination population in Beijing,and to explore the reference range of serum AFP content in healthy people and the relationship with gender and age.Methods Selected from February to October 2019,a total of 10124 patients from the health examination center of the Beijing Jingmei Group General Hospital were selected.The chemiluminescence immunoassay method was used to detect the serum AFP content,and the reference range was established to compare different genders and different age groups.The difference in serum AFP content between the two.Results The reference range of AFP for the normal population tested in this study is 0~7.10 ng/ml.There was a significant difference in the average content of AFP between men and women.There were also differences between men and women of different age groups,ranging from 20 to 69 the average serum AFP levels of healthy men,women and the general population in the age group increased with age,and the AFP levels over 70 years of age decreased,and the positive rate showed a trend of first rising and then decreasing with age.Conclusion The overall AFP reference range of 0~7.10 ng/ml was suitable for screening in this laboratory.The serum AFP content in healthy people was related to gender and age.The positive rate of AFP first increases and then decreases with age.