矛头蝮蛇血凝酶静脉注射联合局部使用对股骨骨折手术患者的止血效果

Hemostatic Effect of Intravenous Injection of Hemocoagulase Bothrops Atrox Combined with Local Use on Patients Undergoing Femoral Fracture Surgery

目的探讨矛头蝮蛇血凝酶静脉注射联合局部使用对股骨骨折手术患者的止血效果。方法选取2018年12月~2019年12月我院收治的股骨骨折手术患者80例作为研究对象,按照随机数字表法分为对照组和研究组,每组40例。对照组单纯静脉注射用矛头蝮蛇血凝酶,研究组注射用矛头蝮蛇血凝酶静脉注射联合局部使用,比较两组止血情况(切口出血量、切口止血时间、单位面积出血量)、术中出血量、术后1 d引流量、围术期凝血因子指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)]。结果研究组切口出血量、切口止血时间、单位面积出血量优于对照组[(5.12±3.05)g vs(8.15±2.69)g]、[(125.88±41.72)s vs(190.32±55.04)s]、[(0.28±0.13)g/cm^2 vs(0.38±0.15)g/cm^2],差异有统计学意义(P<0.05);研究组术中出血量、术后1 d引流量低于对照组,差异有统计学意义(P<0.05);两组术前、术后1 d PT、TT、APTT比较,差异无统计学意义(P>0.05)。结论注射用矛头蝮蛇血凝酶静脉注射联合局部使用应用于股骨骨折手术患者可进一步提升止血效果,减少术中出血量,有利于促进股骨关节恢复,且不会引起凝血功能异常。

Objective To investigate the hemostatic effect of intravenous injection of Hemocoagulase Bothrops Atrox combined with local use on patients with femoral fracture surgery.Methods 80 cases of femoral fracture surgery patients admitted to our hospital from December 2018 to December 2019 were selected as the research objects,and were divided into the control group and the study group according to the random number table method,with 40 cases in each group.In the control group,Hemocoagulase Bothrops Atrox for intravenous injection alone,and Hemocoagulase Bothrops Atrox for intravenous injection in the study group combined with local use.The two groups were compared for hemostasis(incision bleeding,incision hemostasis time,bleeding per unit area),surgery amount of bleeding,the amount of drainage on the first day after surgery,and the perioperative coagulation factor indexes[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)].Results The study group’s incision bleeding,incision hemostasis time,and unit area bleeding were better than those of the control group[(5.12±3.05)g vs(8.15±2.69)g],[(125.88±41.72)s vs(190.32±55.04)s],[(0.28±0.13)g/cm^2 vs(0.38±0.15)g/cm^2],the difference was statistically significant(P<0.05);the amount of blood loss during operation and the amount of drainage 1 d after operation in the study group were lower than those in the control group,there was statistical significance(P<0.05);there was no significant difference in PT,TT,APTT before and 1 d after operation between the two groups(P>0.05).Conclusion The intravenous injection of Hemocoagulase Bothrops Atrox for injection combined with local used in patients with femoral fracture surgery could further improve the hemostatic effect,reduce intraoperative blood loss,and promote the recovery of the femoral joint without causing abnormal blood coagulation.