马来酸依那普利叶酸片对急性心肌梗死并发心衰患者的短期疗效及远期预后观察

Short-term efficacy and long-term prognosis of enalapril folic acid tablets in patients with acute myocardial infarction complicated with heart failure

目的探究马来酸依那普利叶酸片对急性心肌梗死并发心衰患者的短期疗效及远期预后。方法选取2015年11月至2018年11月本院收治的80例急性心肌梗死伴心衰患者为研究对象,依据随机数字表法分为两组,每组40例。在常规治疗基础上,对照组予以依那普利片治疗,观察组予以马来酸依那普利叶酸片治疗,均治疗12个月。比较两组患者治疗前及治疗6个月后N末端脑钠肽前体(NT-proBNP)和同型半胱氨酸(Hcy)水平及治疗12个月后左心室射血分数(LVEF)、左室舒张末期内径(LVED)、左室收缩末期内径(LVSD)。结果治疗后两组患者血浆NT-proBNP、Hcy水平均低于治疗前,差异有统计学意义(P<0.05),且观察组患者血浆NT-proBNP、Hcy水平均显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者LVEF显著高于对照组,LVED、LVSD均显著低于对照组,差异有统计学意义(P<0.05)。结论马来酸依那普利叶酸片相比依那普利片对治疗急性心肌梗死并发心衰患者的临床疗效和预后更好。

Objective To study the short-term effect and long-term prognosis of enalapril folic acid tablets in patients with acute myocardial infarction complicated with heart failure.Methods A total of 80 patients with acute myocardial infarction and heart failure who were hospitalized in our hospital from November 2015 to November 2018 were collected.All patients were divided into two groups according to the random number table method,with 40 cases in each group.On the basis of conventional treatment,the control group was treated with enalapril,and the observation group was treated with enalapril folic acid tablets,for 12 months.The levels of N-terminal brain natriuretic peptide precursor(NT-proBNP)and homocysteine(Hcy)before and 6 months after treatment and the left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVED)and left ventricular end-systolic diameter(LVSD)after 12 months treatmentwere compared between two groups.Results After treatment,the plasma NT-proBNP and Hcy levels of the two groups were significantly lower than before treatment,and the differences are statistically significant(P<0.05).The plasma NT-proBNP and Hcy levels of the observation group were significantly lower than that of the control group,and the differences are statistically significant(P<0.05).After treatment,LVEF of observation group was significantly higher than that of control group,LVED and LVSD were significantly lower than that of control group,and the differences are statistically significant(P<0.05).Conclusion Compared with enalapril,enalapril folic acid tablets have better clinical efficacy and prognosis in the treatment of acute myocardial infarction complicated with heart failure.