脑利钠肽治疗急性心肌梗死合并急性心力衰竭患者的疗效

Therapeutic Effect of Brain Natriuretic Peptide on Patients with Acute Myocardial Infarction Complicated with Acute Heart Failure

目的探讨脑利钠肽治疗急性心肌梗死合并急性心力衰竭患者的临床疗效。方法选取2016年1月至2018年6月台安县恩良医院收治的62例急性心肌梗死合并急性心力衰竭的患者作为研究对象,根据随机原则分为对照组和观察组,每组31例。对照组患者入院后密切观察患者生命体征变化情况,并予以强心、利尿、扩血管、预防血小板凝集及口服β受体阻滞剂等治疗。观察组患者在对照组治疗基础上予以脑利钠肽1.5μg/kg静脉注射,然后再以0.075μg/(kg·min)的剂量静脉滴注。比较两组患者治疗前后的临床疗效、心率、心脏射血分数及B型脑钠肽水平。结果治疗后,两组患者临床症状均得到一定改善,心率和B型脑钠肽水平均较治疗前下降,心脏射血分数较治疗前升高(均P <0.05),且观察组患者临床症状改善更加明显,心率和B型脑钠肽水平下降幅度更大,心脏射血分数提升幅度更高(均P <0.05)。结论脑利钠肽能有效改善急性心肌梗死合并急性心力衰竭患者的心脏供血功能,增强心肌功能,提高临床疗效。

Objective To investigate the clinical effect of brain natriuretic peptide on acute myocardial infarction complicated with acute heart failure.Methods From January 2016 to June 2018,62 patients with acute myocardial infarction and acute heart failure admitted to our hospital were selected as the study subjects.They were randomly divided into the control group and the observation group,with 31 cases in each group.The patients in the control group were treated with anti-heart failure therapy such as cardiotonic,diuretic,vasodilator,prevention of platelet aggregation and oral beta-blocker.The patients in the observation group were given intravenous injection of brain natriuretic peptide 1.5μg/kg on the basis of the treatment in the control group,and then intravenously dripped at the dose of 0.075μg/(kg·min).The clinical effi cacy,heart rate,ejection fraction and B-type brain natriuretic peptide levels were compared between the two groups before and after treatment.Results After treatment,the clinical symptoms of the two groups were improved to a certain extent,the heart rate and B-type brain natriuretic peptide levels decreased,and the ejection fraction of the heart increased(all P<0.05).However,the clinical symptoms of the observation group treated with brain natriuretic peptide improved more obviously,the heart rate and B-type brain natriuretic peptide levels decreased more,and the ejection fraction of the heart increased more(all P<0.05).Conclusion Brain natriuretic peptide can eff ectively improve the cardiac blood supply,enhance myocardial function and improve clinical efficacy in patients with acute myocardial infarction and acute heart failure.