奥沙利铂联合雷替曲塞治疗老年晚期结直肠癌患者的疗效

Efficacy of Oxaliplatin Combined with Raltitrexed in the Treatment of Elderly Patients with Advanced Colorectal Cancer

目的分析奥沙利铂联合雷替曲塞在老年晚期结直肠癌患者中的治疗效果。方法 60例老年结直肠癌患者均为2016年1月至2018年6月朝阳市中心医院所收治,随机将其分为观察组(n=30,奥沙利铂联合雷替曲塞治疗)和对照组(n=30,常规治疗)。比较两组患者的治疗效果及不良反应发生情况。结果观察组患者的治疗总有效率为86.67%,对照组为63.33%,差异有统计学意义(P <0.05);观察组患者的不良反应总发生率低于对照组,差异有统计学意义(P <0.05)。结论针对老年晚期结直肠癌患者,采用奥沙利铂联合雷替曲塞进行治疗具有满意的效果,不仅可抑制肿瘤病情的发展,还能减少传统治疗方法导致的不良反应,这对于延长患者的生存时间、改善预后具有重要意义。

Objective To analyze the therapeutic effect of oxaliplatin combined with raltitrexed in elderly patients with advanced colorectal cancer,and to find an effective method for the intervention of advanced colorectal cancer.Methods All 60 elderly patients with colorectal cancer were admitted to Chaoyang Central Hospital from January 2016 to June 2018.They were randomly divided into observation group(n=30,oxaliplatin combined with raltitrexed treatment)and control group Group(n=30,conventional treatment).The treatment effects and adverse reactions of the two groups of patients were compared.Results The effective rate of the observation group was 86.67%,which was higher than that of the control group(63.33%),the difference between the groups was significant(P<0.05).The number of adverse reactions in the observation group was lower than that in the control group,the difference between the groups was significant(P<0.05).Conclusion In the clinical treatment of advanced colorectal cancer in the elderly,the treatment with oxaliplatin combined with raltitrexed has a satisfactory effect,which can not only inhibit the development of cancer,but also reduce the adverse reactions in traditional treatment methods.Prolonging the survival time of patients and improving the prognosis are of great significance.