应用喹硫平治疗精神分裂症患者的安全性

Safety of Quetiapine in the Treatment of Schizophrenia

目的探讨应用喹硫平治疗精神分裂症患者的安全性。方法选取2018年1月至2019年1月在辽宁省大连市第七人民医院治疗的80例精神分裂症患者,随机分为试验组和对照组,每组40例。对照组采取传统方法治疗,试验组采取喹硫平治疗,治疗后6周,比较两组患者的阳性症状与阴性症状量表(PANSS)、简明精神病量表(BPRS)评分。结果试验组患者的PANSS、BPRS评分均低于对照组,差异均有统计学意义(均P <0.05);试验组患者活动增加或减少、兴奋激越、嗜睡、恶心呕吐、体质量增加等不良反应总发生率低于对照组,差异有统计学意义(P <0.05)。结论在传统治疗基础上应用喹硫平治疗精神分裂症在提高临床有效率的同时,降低药物不良反应,并且有助于提高生活质量。

Objective To study the safety of quetiapine in the treatment of schizophrenia.Methods From January 2018 to January 2019,80 patients with schizophrenia in 7th People's Hospital of Dalian were enrolled and randomly divided into the experimental group and the control group,with 40 cases in each group.The control group was treated with traditional methods,the experimental group was treated with quetiapine.After treatment 6 weeks,the Positive and Negative Symptoms Scale(PANSS),Brief Psychiatric Rating Scale(BPRS)score of two groups were recorded.Results The PANSS score and BPRS score in the experimental group were signifi cantly lower than those of the control group,and the diff erences were statistically signifi cant(all P<0.05).The total incidence of adverse events,such as activities to increase or decrease,excitement agitation,somnolence,nausea and vomiting,weight gain of the experimental group was significantly lower than control group,the diff erence was statistically significant(P<0.05).Conclusion On the basis of traditional treatment,quetiapine in the treatment of schizophrenia patients has a better clinical eff ect,it can signifi cantly reduce the toxic and side effects,improve the quality of life of patients.