推进烷氧基化绿色工艺发展,培养学生专业思维能力——以甲氧基化反应的进步为例

Promoting Green Alkoxylation Processes Development and Cultivating Students′Professional Thinking Ability--Taking Developed Methoxylation as an Example

基于研究成熟的非活化溴代芳烃甲氧基化反应的机理,借助锂离子亲氧性,一种廉价、具有原子经济性、洁净高效的绿色反应体系被应用到铜催化非活化溴代芳烃的短链烷氧基化反应中,且进一步用于对药物发现有重要意义的氟代烷基芳基醚化合物的绿色合成。教学中介绍这一渐进的工艺发展历程,有助于逐步培养学生的创新性专业思维能力。

Based on the well-studied methoxylation and reaction mechanism of unactivated bromoarenes,the green reaction system embodied in cost,atom and recycle-economy has been carried forward to the copper-catalyzed short-chain alkoxylation of unactivated aryl bromides,with the help of oxyphile of lithium-ion.Furthermore,the green process has been extended again to the synthesis of fluoroalkyl aryl ethers possessing,which is important to drug discovery.Through introcuding the gradual technological development,teachers could cultivate students′innovative professional thinking ability.