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利用电感耦合等离子体原子发射光谱法检测塑料类输液容器中多种金属元素与离子的可行性研究 被引量:5

Feasibility Study on Detection of Metal Elements and Ions in Plastic Infusion Containers by ICP⁃OES
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摘要 出于快速、准确和经济角度,采用电感耦合等离子体原子发射光谱法(ICP⁃OES法)测定塑料类输液容器中金属元素和金属离子含量。按照《国家药包材标准》(2015版)的方法得到待测液后,利用ICP⁃OES测定金属元素和金属离子的含量,并对测定方法进行了方法学考察。通过与《国家药包材标准》规定的原子吸收法进行比较,筛选出最佳的检测方案。结果表明,ICP⁃OES法中,铅、镉、铜、铝、钡、锡、铬的谱线选择分别为220.353、214.438、324.754、167.079、445.403、189.989、283.563 nm;检出限分别为2.09、0.05、0.67、0.60、0.32、0.88、0.90 ng/mL;精密度(20 ng/mL)分别为2.53%、0.12%、0.96%、0.42%、0.33%、1.22%、1.55%;金属元素的加标回收率分别为80.71%~113.95%,金属离子的加标回收率分别为72.30%~129.36%;ICP⁃OES法能够快速、准确地测定塑料类输液容器中金属元素和金属离子的含量。 To gain a rapid,accuracy and economic test result,an inductively coupled plasma atomic emission spectrometry(ICP⁃OES)method was adopted to detect the contents of metal elements and metal ions in plastic infusion containers.The test samples were treated according to the method of National standards for package of medicine(2015).The solu⁃tion containing the test sample was directly analyzed by the ICP⁃OES,and the methodological investigation was carried out.The optimum detection scheme was selected by comparing with the standard atomic absorption method.Based on the analysis of test results,the spectral lines of lead,cadmium,copper,aluminum,barium,tin and chromium were deter⁃mined as 220.353,214.438,324.754,167.079,445.403,189.989 and 283.563 nm,respectively.The detection limits were 2.09,0.05,0.67,0.60,0.32,0.88 and 0.90 ng/mL,respectively.The precisions at 20 ng/mL were determined as 2.53%,0.12%,0.96%,0.42%,0.33%,1.22%and 1.55%,respectively.The recovery rates of metal ele⁃ments and ions were determined as 80.71%~113.95%and 72.30%~129.36%,respectively.The ICP⁃OES method can be used to determine the contents of metal elements and ions in plastic infusion containers quickly and accurately.
作者 武静文 WU Jingwen(Chongqing Institute for Food and Drug Control,Chongqing 401121,China)
出处 《中国塑料》 CAS CSCD 北大核心 2020年第9期73-79,共7页 China Plastics
基金 重庆市科学技术局(cstc2019jxjl130040)。
关键词 电感耦合等离子体原子发射光谱法 原子吸收法 金属元素 金属离子 塑料类输液容器 inductively coupled plasma atomic emission spectrometry atomic absorption method metal elements metal ions plastic infusion containers
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