瞬时受体电位通道蛋白A1在疼痛中的研究进展

Research progress in transient receptor potential channel A1 in pain

疼痛是一种与组织损伤或潜在组织损伤相关的感觉、情感、认知和社会维度的痛苦体验。近年来很多报道表明瞬时受体电位阳离子通道家族(transient receptor potential cation channel,TRPs)中的瞬时受体电位通道蛋白A1(transient receptor potential channel A1,TRPA1)通道参与温度、机械、炎症刺激等引起的不同类型疼痛反应,并且通过多种路径发挥作用。文章从TRPA1的分子结构、表达部位、其激动及拮抗物质的角度出发,探讨其参与不同类型疼痛的机制,对目前关于TRPA1在疼痛治疗中的研究进展进行综述,为开发新的镇痛药物提供参考依据。

Pain is a painful experience of feeling in emotion,cognition and social dimensions related to tissue damage or potential tissue damage.In the recent years,many reports have shown that transient receptor potential channel A1(TRPA1)channels in transient receptor potential cation channel(TRP)are involved in various types of pain reactions caused by temperature,mechanical,and inflammatory stimuli,and function though multiple pathways.This article discusses the mechanisms by which TRPA1 involves in different types of pain based on the molecular structure,expression location,and activation antagonists of TRPA1,reviews the current research progress in TRPA1 in pain treatment,and provides reference for the development of new analgesics.