摘要
肝脏依靠肝细胞的自我更新和肝卵圆细胞(HOC)的增殖分化两大途径参与肝损伤的修复。HOC是一类具有多向分化潜能的肝干细胞,在肝脏再生中扮演重要角色。肝硬化肝细胞再生能力低下,HOC参与肝脏损伤的修复和重建,其活化,增殖及分化等与肝硬化微环境密切相关。因此,深入研究HOC在肝硬化中介导肝脏再生的机制及细胞移植的优势,将为治疗终末期肝硬化提供新策略。笔者就HOC的特征、其在肝硬化微环境下的作用、以及肝硬化微环境对HOC介导肝脏再生的调控等研究进展进行综述。
The liver depends on two mechanisms—hepatocyte self-renewal and proliferation and differentiation of the hepatic oval cells (HOCs) to obtain the repair of liver injury.HOCs are a group of hepatic stem cells with multipotent differentiation potential,and play an important role in liver regeneration.The regeneration ability of the hepatocytes in the cirrhotic liver is low,and HOCs participate in the repair and reconstruction of liver damage.The activation,proliferation and differentiation of HOCs are closely associated with the liver cirrhosis microenvironment.So,the in-depth study on the mechanism of the HOCs-mediated liver regeneration in liver cirrhosis and their advantages in cell transplantation in liver cirrhosis will provide a new strategy for the treatment of end-stage liver cirrhosis.Here,the authors address the general features of the HOCs and the research progress regarding such as their function in the liver cirrhosis microenvironment and the regulation of the liver cirrhosis microenvironment in HOCs-mediated liver regeneration.
作者
樊爽
赵建国
王震侠
FAN Shuang;ZHAO Jianguo;WANG Zhenxia(A Area,Department of Hepatobiliary and Pancreatosplenic Surgery,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2020年第8期1006-1011,共6页
China Journal of General Surgery
基金
内蒙古自治区自然科学基金资助项目(2018MS08079)
内蒙古医科大学附属医院肝胆胰外科院士专家工作站建设基金资助项目。
关键词
肝硬化
卵圆细胞
肝再生
干细胞
综述
Liver Cirrhosis
Oval cells
Liver Regeneration
Stem Cells
Review