二胎产妇的D-二聚体、凝血功能分析与头胎产妇对比

Analysis of Comparison about D-Dimer and Coagulation Function Between Second-Born and First-Born Women

目的对比分析二胎产妇与头胎产妇D-二聚体以及凝血功能差异。方法选择2018年1月至6月在我院待分娩产妇519例,其中包括头胎产妇310例(头胎组)、二胎产妇209例(二胎组),此外,随机抽取同期在我院健康体检的非妊娠期健康妇女150例作为对照组,检测3组受试者血浆D-二聚体及凝血功能并进行比较分析。结果 3组受试者在APTT、TT、PT比较差异无统计学意义(P>0.05),而3组受试者D-二聚体、FIB比较差异有统计学意义(P<0.05),产妇组D-二聚体、FIB较对照组显著升高(P<0.05),其中二胎组D-二聚体、FIB显著高于头胎组(P<0.05)。不同年龄段头胎产妇APTT、TT、PT比较差异无统计学意义(P>0.05),而年龄≥34岁头胎产妇D-二聚体以及FIB水平显著高于年龄<29岁及29~34岁头胎产妇(P<0.05)。不同年龄段二胎产妇APTT、TT、PT比较差异无统计学意义(P> 0.05),而年龄≥34岁二胎产妇D-二聚体以及FIB水平显著高于年龄<29岁及29~34岁二胎产妇(P<0.05)。头胎产妇与二胎产妇D-二聚体及FIB水平均与产妇年龄呈显著正相关关系(P<0.05)。结论二胎产妇血液高凝状态较头胎产妇更为严重,主要考虑胎次与年龄对机体的共同影响结果,在临床工作中,需要加强对高龄二胎产妇凝血功能的检测,预防静脉血栓性疾病的发生,改善产妇妊娠结局。

Objective To compare and analyze the difference of D-dimer and coagulation function between second-born andfirst-born women. Methods 519 parturients were selected from January 2018 to June 2018 in our hospital,including 310 first-bornwomen( first-born group) and 209 second-bornwomen( second-born group). In addition,150 healthy non-pregnant women were randomly selected as control group.The plasma D-dimer and coagulation function of each group were detected and compared.Results There were no significant differences in APTT,TT and PT among three groups( P > 0. 05),but there were significant differences in D-dimer and FIB among three groups( P < 0. 05). D-dimer and FIB in maternal group were significantly higher than those in control group( P<0. 05).D-dimer and FIB in second-born group were significantly higher than those in first-born group( P<0. 05).There were no significant differences in APTT,TT and PT among first-born women of different ages( P > 0. 05),but for first-born womenaged over 34 years,D-dimer and FIB were significantly higher than those aged < 29 years and 29 ~ 34 years( P<0. 05).There was no significant difference in APTT,TT and PT among second-born women of different ages( P>0. 05),but D-dimer and FIB in second-born women aged over 34 years were significantly higher than those in second-born women aged < 29 years and 29 ~ 34 years( P < 0. 05). Conclusion The blood hypercoagulability of second-born women is more serious than that of first-born women,mainly considering the joint effect of parity and age on the body.In clinical work,it is necessary to strengthen the detection of coagulation function of elderly second-born women to prevent venous thrombosis diseases and improve pregnancy outcome.