Bio-Oss骨代用品同引导骨再生膜联合应用效果的观察

A clinical and histological study of Bio-Oss in combination with guided bone regeneration membrane technique

目的 通过组织学观察Bio Oss作为骨移植材料同引导骨再生膜技术联合应用治疗牙槽骨局部骨缺损及种植体周围骨缺损的临床效果。方法 从 6例牙槽骨局部缺损患者的 6处骨再生区取少量骨组织 ,采取Donath硬组织切片磨片技术行组织学观察。结果 组织学显示淡红色新生骨同淡黄色的Bio Oss颗粒区别明显 ,Bio Oss颗粒表面有新骨形成 ,并与之紧密结合。未见纤维结缔组织长入包裹Bio Oss颗粒及炎症细胞浸润。结论 Bio Oss骨有良好的生物相容性和骨引导作用 。

Objective To evaluate the reliability of Bio Oss particles as bone grafts in combination with membrane technique. Methods 6 small biopsy specimens were retrieved without causing iatrogenic damage in 6 patients (implant sites). The Donath′s hard tissue section and micro grinding technique was adopted, and Leval Laczko staining method was used. Results The histological results showed Bio Oss particles were easily distinguished from the newly formed bone , but new bone was formed among different particles of Bio Oss, no connective tissue was found. Intimate contact between newly formed bone and particles of the graft was present. Conclusions Bio Oss appears to be highly biocompatible and osteoconductive. It can be used success fully as a bone substitute in combination with guided bone regeneration membrane technique.