麦默通乳腺微创旋切术治疗乳腺良性肿瘤的临床效果研究

Study on the clinical effect of minimally invasive mastectomy with Mammotome in the treatment of breast benign tumor

目的研究麦默通乳腺微创旋切术治疗乳腺良性肿瘤的临床效果。方法选取安吉县人民医院2017年1月至2018年12月收治的乳腺良性肿瘤患者800例开展前瞻性研究,采用随机数字表法分为对照组400例、观察组400例,对照组行开放乳腺肿瘤切除术,观察组实施麦默通乳腺微创旋切术。比较两组手术情况、术后并发症发生率、术后恢复时间、乳房外观美学效果、血清炎性因子指标、细胞免疫功能。结果观察组手术用时、术中出血量分别为(17.59±8.23)min、(23.57±7.64)mL,均短于、少于对照组的(29.83±11.91)min、(54.28±17.59)mL(t=16.910、30.027,均P<0.05);观察组术后并发症发生率为1.50%(6/400),低于对照组的5.75%(23/400)(χ2=10.340,P<0.05);观察组术后切口愈合时间、住院时间分别为(4.07±1.39)d、(5.58±2.31)d,均短于对照组的(5.56±1.75)d、(7.92±2.78)d(t=13.334、12.948,均P<0.05);观察组乳房外观美学优良率为97.25%(389/400),高于对照组的89.25%(357/400)(χ2=20.336,P<0.05)。手术后,观察组血清炎性因子各项指标均较对照组低(t=17.360、14.717、14.109,均P<0.05)。两组手术后的CD3+、CD4+/CD8+均较手术前降低(对照组t=20.788、16.121,观察组t=11.616、8.348,均P<0.05),而观察组的CD3+、CD4+/CD8+均较对照组高(t=10.655、7.328,均P<0.05)。结论麦默通乳腺微创旋切术可有效减轻乳腺良性肿瘤患者的手术创伤,减少其术后并发症,减轻对其细胞免疫功能的影响,有利于加快术后恢复速度,改善乳房外观。

Objective To study the clinical effect of Mammotome minimally invasive breast circumcision in the treatment of breast cancer.Methods A prospective study was carried out in 800 breast benign tumor patients admitted to the People's Hospital of Anji County from January 2017 to December 2018.The patients were divided into control group(400 cases)and observation group(400 cases)according to the random digital table method.The control group received open breast tumor resection,and the observation group received minimally invasive mastectomy.The postoperative complications,recovery time,aesthetic effect of breast appearance,serum inflammatory factors and cellular immune function were compared between the two groups.Results The operation time and bleeding volume in the observation group were(17.59±8.23)min,(23.57±7.64)mL,respectively,which were lower than those in the control group[(29.83±11.91)min,(54.28±17.59)mL](t=16.910,30.027,all P<0.05).The incidence of postoperative complications in the observation group was 1.50%(6/400),which was lower than 5.75%(23/400)in the control group(χ2=10.340,P<0.05).The time of incision healing and hospitalization in the observation group were(4.07±1.39)d,(5.58±2.31)d,respectively,which were shorter than those in the control group[(5.56±1.75)d,(7.92±2.78)d](t=13.334,12.948,all P<0.05).The excellent and good rate of breast appearance aesthetics in the observation group was 97.25%(389/400),which was higher than 89.25%(357/400)in the control group(χ2=20.336,P<0.05).After operation,the serum levels of inflammatory factors in the observation group were lower than those in the control group(t=17.360,14.717,14.109,all P<0.05).CD3+and CD4+/CD8+in the two groups were lower than before operation(control group:t=20.788,16.121;observation group:t=11.616,8.348,all P<0.05),and CD3+and CD4+/CD8+in the observation group were higher than those in the control group(t=10.655,7.328,all P<0.05).Conclusion Mammotome minimally invasive mastectomy can effectively reduce the surgical trauma of breast cancer patients,reduce the postoperative complications,reduce the impact on their cellular immune function,and help to speed up the recovery and improve the appearance of breast.