儿童失神癫痫40例注意网络测试分析

A study on attention network of children with absence epilepsy

目的分析儿童失神癫痫(CAE)注意网络损害特征。方法选取2017年11月至2018年9月就诊于安徽医科大学附属省儿童医院CAE患儿40例及在该院体检的健康儿童40例,运用改良版的注意网络测试工具(ANT)分别进行注意网络检查。结果CAE组患儿注意网络检查正确率为(94.98±2.20)%,低于对照组的(97.58±1.52)%,两者差异有统计学意义(t=6.151,P<0.001);CAE组患儿注意网络检查总平均反应时为(1076.95±190.32)ms,显著长于对照组的(863.85±200.00)ms,两者差异有统计学意义(t=4.882,P<0.001);CAE组患儿的警觉网络效率为(43.18±48.98)ms,显著低于对照组的(66.18±37.37)ms,差异有统计学意义(t=2.361,P<0.05);CAE组患儿的执行控制网络效率为(103.65±58.72)ms,显著低于对照组的(72.28±42.56)ms,差异有统计学意义(t=2.736,P<0.05);CAE组患儿的定向网络效率为(26.73±45.10)ms,低于对照组的(29.45±27.15)ms,但差异无统计学意义(t=0.327,P>0.05)。发病年龄是影响CAE患儿注意网络检查总平均反应时长的相对独立危险因素。结论CAE患儿存在注意网络的损害,且其发病年龄是CAE患儿注意网络损害的临床相关危险因素。

Objective To analyze the characteristics of childhood absence epilepsy(CAE)attentional network damage.Methods A total of 40 CAE children and 40 healthy children who received physical examination in the Provincial Children's Hospital Affiliated to Anhui Medical University from November 2017 to September 2018 were selected for online examination by using the improved attention netwoks test(ANT).Results The accuracy rate of attention network examination in CAE children[(94.98±2.20)%]was lower than that in the healthy control group[(97.58±1.52)%],and the difference was statistically significant(t=6.151,P<0.001).The total mean response time of the CAE group[(1076.95±190.32)ms]was significantly longer than that of the control group[(863.85±200.00)ms],and the difference was statistically significant(t=4.882,P<0.001).The alertness network efficiency in the CAE group[(43.18±48.98)ms]was significantly lower than that in the control group[(66.18±37.37)ms],the difference was statistically significant(t=2.361,P<0.05).The executive control network efficiency in the CAE group[(103.65±58.72)ms]was significantly lower than that in the control group[(72.28±42.56)ms],and the difference was statistically significant(t=2.736,P<0.05).The directional network efficiency of the CAE group[(26.73±45.10)ms]was lower than that of the control group[(29.45±27.15)ms],but the difference was not statistically significant(t=0.327,P>0.05).Age of onset was a relatively independent risk factor affecting the total mean response time of ANT in children.Conclusion This study has proved that children with CAE have damage to attention network,and their age of onset is a clinically relevant risk factor for the level of attention network in them.