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鼻咽部人免疫缺陷病毒感染相关CD30阳性弥漫性大B细胞淋巴瘤一例

CD30 positive diffuse large B cell lymphoma associated with human immunodeficiency virus infection in nasopharynx:report of a case
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摘要 人免疫缺陷病毒(HIV)感染相关鼻咽部弥漫性大B细胞淋巴瘤是一种罕见恶性肿瘤,临床诊断困难,主要依靠病理学检查确诊。患者男,35岁。鼻内镜检查见右侧鼻咽部一肿物,表面光滑,下极呈分叶状,触之柔软。送检标本为灰白色碎组织,镜下见淋巴样组织弥漫增生。免疫组织化学染色示大细胞呈CD20、CD79a、CD30阳性;背景小细胞呈CD3和CD45RO阳性。原位杂交示大细胞呈EB病毒编码的小RNA(EBER)阳性。血清学检查示HIV阳性。患者接受抗病毒及R-CHOP(利妥昔单抗、环磷酰胺、多柔比星、长春新碱、泼尼松龙)方案治疗,一般情况良好。
作者 王青青 潘云 Wang Qingqing;Pan Yun(School of Basic Medical Science,Dali University,Yunnan Province,Dali 671000,China;Department of Pathology,the First Affiliated Hospital of Dali University,Yunnan Province,Dali 671000,China)
出处 《中华病理学杂志》 CAS CSCD 北大核心 2020年第9期952-953,共2页 Chinese Journal of Pathology
基金 国家自然科学基金(81660037、81960042) 云南省研究生导师团队项目(云学位〔2019〕16号) 云南省高校重点实验室项目(云教科〔2016〕37号) 大理大学创新团队项目(理大校发〔2019〕13号)。
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