线粒体与脑疾病

Mitochondrial dysfunction and related brain diseases

线粒体通过氧化磷酸化途径为机体提供大部分能量,并且参与细胞信号传导、炎症反应、细胞凋亡等多种生理生化过程。大脑对线粒体能量供应的变化十分敏感,线粒体功能障碍可通过多种途径的相互作用,参与遗传代谢性脑疾病、神经退行性脑疾病、精神心理脑疾病和脑老化等的发生发展过程。目前线粒体相关脑疾病尚缺乏特效治疗方案,线粒体的基因靶向治疗研究有望突破线粒体病的治疗瓶颈,为患者带去希望。

Mitochondria provides most of the energy for the body through oxidative phosphorylation(OXPHOS)and participates in various physiological and biochemical processes such as cell signal transduction,inflammatory response and apoptosis.Brain is very sensitive to energy change.Mitochondrial dysfunction is associated with various disorders including genetic and metabolic diseases,neurodegenerative diseases,psychological diseases and brain aging via multiple pathways.At present,there is no specific treatment plan for mitochondrial encephalopathy.Research on mitochondrial gene targeted therapy is expected to break through the treatment bottleneck of mitochondrial diseases and brings hope to patients.