地夸磷索钠在泪液异常相关角结膜上皮损伤患者中的应用

Application of Diquafosol on tear-film dysfunction-related corneal and conjunctival epithelial damage

3%地夸磷索钠滴眼液作为P2Y2受体激动剂,可以促进泪膜中水液和黏蛋白成分的分泌,同时促进角结膜上皮损伤的修复,填补了我国眼科领域中针对水分及黏蛋白缺乏所致的泪液异常造成的角结膜上皮损伤的治疗空白。本文就3%地夸磷索钠的作用机制及其对泪液异常导致的角结膜上皮损伤修复进行综述,为此类患者临床治疗提供理论依据。

As a P2Y2 receptor agonist,Diquafosol used as a 3% solution can promote tear fluid and mucin secretion and accelerate the healing of corneal and conjunctival epithelium.It fills an unmet need in ophthalmology in China for the treatm ent of corneal and conjunctival epithelium injury caused by aqueous solutions and mucin deficiency.This article reviews the mechanism's of 3% Diquafosol in the healing of corneal and conjunctival epithelial damage,hoping to provide a theoretical basis for clinical practice.