摘要
目的探讨肾功能不全患者N端B型脑利钠肽前体(NT-proBNP)和肌红蛋白水平的变化及临床意义。方法根据美国慢性肾脏病分期,利用估算肾小球滤过率(eGFR)水平将389例肾科住院患者分为五组:A组41例,eGFR≥90 mL·min^-1·1.73m^-2;B组34例,60 mL·min^-1·1.73m^-2≤eGFR<90 mL·min^-1·1.73m^-2;C组65例,30 mL·min^-1·1.73m^-2≤eGFR<60 mL·min^-1·1.73m^-2;D组104例,15 mL·min^-1·1.73m^-2≤eGFR<30 mL·min^-1·1.73m^-2;E组145例,eGFR<15 mL·min^-1·1.73m^-2。比较五组患者NT-proBNP和肌红蛋白水平,分析NT-proBNP和肌红蛋白与SCr和eGFR的相关性。结果A、B、C、D和E组NT-proBNP水平分别为247.4(86.1,1494.5)ng/L、431.7(124.3,1387.0)ng/L、621.7(234.5,3404.5)ng/L、1568.0(620.9,5440.3)ng/L和8571.0(4914.0,15832.5)ng/L,肌红蛋白水平分别为19.0(14.0,26.5)μg/L、22.5(18.5,35.3)μg/L、51.0(29.5,107.0)μg/L、56.0(37.5,86.8)μg/L和110.0(76.0,182.5)μg/L。E组NT-proBNP和肌红蛋白水平高于C、D组(P<0.05)。NT-proBNP和肌红蛋白均与SCr呈正相关(rs=0.631和0.620,P<0.05),与eGFR呈负相关(rs=-0.640和-0.601,P<0.05)。结论NT-proBNP和肌红蛋白水平随着肾脏疾病的进展而增加,动态检测有助于早期发现肾功能不全患者的心血管疾病。
Objective To investigate the change and clinical significance of N-terminal brain natriuretic peptide precursor(NT-proBNP)and myoglobin in the patients with renal insufficiency.Methods According to the US CKD staging,389 hospitalized patients in nephrology department were divided into five groups of A(eGFR≥90 mL·min^-1·1.73 m^-2,41 cases),B(60 mL·min^-1·1.73 m^-2≤eGFR<90 mL·min^-1·1.73 m^-2,34 cases),C(30 mL·min^-1·1.73 m^-2≤eGFR<60 mL·min^-1·1.73 m^-2,65 cases),D(15 mL·min^-1·1.73 m^-2≤eGFR<30 mL·min^-1·1.73 m^-2,104 cases)and E(eGFR<15 mL·min^-1·1.73 m^-2,145 cases).The levels of NT-proBNP and myoglobin were compared among five groups,and the correlations of NT-proBNP and myoglobin with SCr and eGFR were analyzed.Results The NT-proBNP level in groups of A,B,C,D and E was 247.4(86.1,1494.5)ng/L,431.7(124.3,1387.0)ng/L,621.7(234.5,3404.5)ng/L,1568.0(620.9,5440.3)ng/L and 8571.0(4914.0,15832.5)ng/L,respectively.The myoglobin level in groups of A,B,C,D and E was 19.0(14.0,26.5)μg/L,22.5(18.5,35.3)μg/L,51.0(29.5,107.0)μg/L,56.0(37.5,86.8)μg/L and 110.0(76.0,182.5)μg/L,respectively.The levels of NT-proBNP and myoglobin were higher in group E than those in groups of C and D(P<0.05).NT-proBNP and myoglobinin were positively correlated with SCr(rs=0.631 and 0.620,P<0.05)and negatively correlated with eGFR(rs=-0.640 and-0.601,P<0.05).Conclusion The levels of NT-proBNP and myoglobin are increased with the progression of kidney disease,which is helpful for early detection of cardiovascular diseases in the patients with renal insufficiency.
作者
王敏
臧晓陵
王荣琥
丁红梅
WANG Min;ZANG Xiaoling;WANG Ronghu(Department of Laboratory Medicine,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA)
出处
《江苏医药》
CAS
2020年第8期816-818,共3页
Jiangsu Medical Journal
基金
江苏省实验诊断学重点实验室基金(ZDXKB2016005)
江苏省高校优势学科建设工程资助项目(JX10231802)。
关键词
N端B型脑利钠肽前体
肌红蛋白
血清肌酐
肾小球滤过率
肾功能不全
N-terminal brain natriuretic peptide precursor
Myoglobin
Serum creatinine
Glomerular filtration rate
Renal insufficiency