摘要
AIM:To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis.METHODS:A retrospective comparative cohort study.Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled.Choroidal thickness(CT)and choroidal vascularity index(CVI)were measured in both affected and the fellow eyes at baseline,1 wk.1 and 3 mo.Changes in CT and CVI were analyzed in both eyes and compared between eyes.RESULTS:The mean CT and CVI were 349μm and 0.70 in the affected eyes and 340μm and 0.69 in the fellow eyes at baseline(P=0.503 and 0.440,respectively).Decrement of CT and CVI at month 3 were significant in affected eyes(P=0.017 and P<0.001).Decreased CVI began 2 wk after treatment whereas CT decreased from 1 mo.The CVI also decreased significantly in fellow eyes at 3 mo compared to the baseline(P=0.001).CONCLUSION:A significant decrement in CT and CVI can appear after 3 mo in optic neuritis patients treated with high-dose systemic corticosteroid treatment.The decrease in CVI appeared earlier than the decrease in CT,suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism.
