膝骨关节炎合并高血压患者血清COMP水平及其与左室肥厚的相关性

Correlation between serum COMP level and left ventricular hypertrophy in patients with knee osteoarthritis com-plicated with hypertension.

目的研究膝骨关节炎合并高血压患者血清软骨寡聚基质蛋白(COMP)水平的变化,并探究其与高血压左室肥厚(LVH)之间的相关性.方法选取膝骨关节炎患者129例,经心血管内科会诊判断其是否伴有高血压及左室肥厚分为高血压组(HP组)、高血压伴左室肥厚组(HLVH组)和单纯骨关节炎组(对照组);比较各组患者血清COMP水平及总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,同时行心脏彩色多普勒超声检测各组患者左心室舒张末期内径(LVDd)、室间隔厚度(VST)、左室后壁厚度(PW),并比较各组患者左室质量指数(LVMI).结果(1)HP组体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、TG、TC水平显著高于对照组,同时HLVH组BMI、SBP、DBP、TG、TC水平显著高于HP组和对照组;(2)HP组COMP、PW及LVMI水平显著高于对照组,HLVH组COMP、LVDd、IVS、PW及LVMI水平显著高于HP组和对照组(P<0.05);(3)血清COMP与LVMI呈正相关(r=0.88,P<0.001),LVMI与SBP、DBP、TG及TC也呈正相关(r=0.70、0.78、0.57、0.63,P<0.05);(4)以LVMI为因变量,以COMP、SBP、DBP、TG、TC为自变量,结果显示,COMP、SBP、DBP、TG进入多元线性回归方程.结论骨关节炎合并高血压左室肥厚患者有较高的血清COMP水平,骨关节炎患者血清COMP水平与左室肥厚的发生发展密切相关.

Objective To study the changes of serum carilage oligomeric matrix protein(COMP)levels in pa-tients with knee osteoarthritis and hypertension,and to explore the correlation between them and left ventricular hypertro-phy(LVH).Methods A total of 129 patients with knee osteoarthritis admitted to the Orthopaedics Department of Luohe Central Hospital from June 2017 to June 2019 were selected,and divided into hypertension group(HP group),hyperten-sion with left ventricular hypertrophy group(HLVH group)and simple osteoarthritis group(control group).Cardiovascu-lar medical consultation was applied for diagnosis of hypertension and left ventricular hypertrophy.Serum COMP,triglyc-eride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cho-lesterol(HDL-C)levels were compared among the 3 groups.At the same time,the left ventricular end-diastolic diam-eter(LVDd),interventricular septal thickness(VST),left ventricular posterior wall thickness(PW)were measured by cardiac color Doppler ultrasonography,and the left ventricular mass index(LVMI)of each group was compared.Results The levels of BMI,SBP,DBP,TG and TC in the HP group were significantly higher than those in the control group.The levels of BMI,SBP,DBP,TG and TC in the HLVH group were significantly higher than those in the HP group and the control group.The levels of COMP,PW and LVMI in the HP group were significantly higher than those in the control group.The levels of COMP,LVDd,IVS,PW and LVMI in the HLVH group were significantly higher than those in the HP group and the control group(P<0.05).There was a significant positive correlation between serum COMP and LVMI(r=0.88,P<0.001).There were also significant positive correlations between LVMI and SBP,DBP,TG and TC(r=0.70,0.78,0.57,0.63;P<0.05).Taking LVMI as the dependent variable and COMP,SBP,DBP,TG and TC as independent variables,the results show that COMP,SBP,DBP and TG enter the multiple linear regression equation.Con-clusion Patients with osteoarthritis complicated with hypertensive left ventricular hypertrophy have higher serum COMP levels.Serum COMP in patients with osteoarthritis is closely correlated to the occurrence and development of HLVH.