肝硬化患者合并胆囊结石的危险因素分析

Risk Factors of Gallstones in Patients with Liver Cirrhosis

目的探讨肝硬化患者发生胆囊结石的危险因素。方法共纳入128例就诊于某三甲医院明确诊断为肝硬化的患者;入组病人通过是否合并胆囊结石分为观察组(45例)和对照组(83例);比较两组患者在年龄、性别、肝功能Child-pugh分级、谷氨酰转肽酶(GGT)、总胆红素(TBIL)、间接胆红素(IBIL)、直接胆红素(DBIL)、甘油三酯(TG)、总胆固醇(TC)、白蛋白(ALB)指标间的差异。结果入组128例肝硬化患者胆囊结石发生率约35.15%。单因素分析显示观察组和对照组在年龄、肝功能Child-Pugh分级、白蛋白水平差异有统计学意义(P<0.05),其余研究指标差异无统计学意义。结论年龄、白蛋白水平、肝功能Child-pugh分级是肝硬化患者合并胆囊结石的危险因素。

Objective To investigate the risk factors of gallstones in patients with cirrhosis.Methods 128 patients admitted to a third-level first-class hospital for definite diagnosis of cirrhosis were included.The patients were divided into observation group(45 cases in total)and control group(83 cases in total)by the combination of gallstones.To analyze and compare the differences in age,gender,liver function child-pugh grading,glutamyl transpeptidase(GGT),total bilirubin(TBIL),indirect bilirubin(IBIL),direct bilirubin(DBIL),triglyceride(TG),total cholesterol(TC)and albumin(ALB)between the two groups.Results The incidence of gallstones in 128 patients with liver cirrhosis was about 35.15%.Single-factor analysis showed that the differences in age,liver function child-pugh grading and albumin level between the observation group and the control group were statistically significant(P<0.05),while the differences in other study indicators were not statistically significant.Conclusion Age,albumin level,and child-pugh grading of liver function are risk factors for gallstones in patients with cirrhosis.