多西他赛联合顺铂化疗联合放疗治疗中晚期宫颈癌的疗效及预后观察

Efficacy and Prognosis of Docetaxel Combined with Cisplatin Chemotherapy and Radiotherapy for Advanced Cervical Cancer

目的观察多西他赛联合顺铂化疗联合放疗治疗中晚期宫颈癌的疗效及预后。方法选取中晚期宫颈癌患者128例,随机分为两组,每组64例。观察组采用多西他赛联合顺铂化疗联合放疗治疗,对照组采用放疗治疗。首次随访时,比较两组总有效率及并发症发生情况;比较两组治疗3年后的生存率、局部复发率、远处转移率;采用SF36评分评估两组患者治疗前及治疗3个月后的生存质量。结果观察组总有效率、生存率高于对照组(P<0.05),局部复发率、远处转移率低于对照组(P<0.05),SF36评分高于对照组(P<0.05),两组并发症发生率差异无统计学意义(P>0.05)。结论多西他赛联合顺铂化疗联合放疗治疗中晚期宫颈癌有效率高,能改善患者的生存质量。

Objective To observe the efficacy and prognosis of docetaxel combined with cisplatin chemotherapy and radiotherapy for advanced cervical cancer.Methods A total of 128 patients with advanced cervical cancer were randomly divided into two groups,64 cases in each group.The observation group was treated with docetaxel plus cisplatin chemotherapy combined with radiotherapy,and the control group was treated with radiotherapy.At the first follow-up,the total effective rate and complications were compared between the two groups.The survival rate,local recurrence rate and distant metastasis rate of the two groups after 3 years of treatment were compared.The SF36 score was used to assess the quality of life of the two groups before treatment and 3 months after treatment.Results The total effective rate and survival rate of the observation group were higher than those of the control group(P<0.05).The local recurrence rate and distant metastasis rate were lower than those of the control group(P<0.05),and the SF36 score was higher than that of the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Docetaxel combined with cisplatin chemotherapy and radiotherapy is effective in the treatment of advanced cervical cancer and can improve the quality of life of patients.