脂质硬皮症研究进展

Research progress on lipodermatosclerosis

脂质硬皮症(LDS)是下肢慢性静脉功能不全(CVI)进展过程中伴发的一种较为严重的皮肤改变,临床可分为急性期、亚急性期和慢性期。该病常见于中年女性,好发于小腿下1/3处,临床表现为小腿皮肤片状红斑、硬结、色素沉着,皮肤粗糙增厚,患者多因瘙痒搔抓后继发感染,重者可形成难愈性溃疡甚至引起皮肤坏死,且有癌变可能。目前国内关于LDS的报道较少。该文就LDS的临床表现、病因、发病机制和治疗进行综述,以加深对LDS的认识,为LDS的临床诊断和治疗提供依据。

Lipodermatosclerosis(LDS)is a serious skin change associated with the progression of chronic venous insufficiency(CVI)of the lower extremities,and can be clinically divided into acute phase,subacute phase and chronic phase.The disease is common in middle-aged women,prone to occur in the lower leg 1/3,clinical manifestations of the skin flake erythema,induration,pigmentation,skin rough and thickening.The patients often suffer from secondary infection after scratching due to pruritus.The severe ones can form refractory ulcer or even cause skin necrosis,and may be canceration.At present,domestic reports on LDS are less,the clinical manifestations,etiology,pathogenesis and treatment of the LDS are reviewed in present paper,in order to strengthen the understanding of LDS and provide the evidence for clinical diagnosis and treatment of LDS.