超声雾化联合奥洛他定治疗儿童过敏性结膜炎的疗效观察

The clinical observation of ultrasonic atomization combined with olopatadine for allergic conjunctivitis in children

目的观察超声雾化联合奥洛他定治疗儿童过敏性结膜炎的疗效。方法利用随机方法将2017年3月至2019年12月在北京京都儿童医院眼科确诊为过敏性结膜炎106例(212眼)患儿分为两组,观察组(56例)给予超声雾化联合奥洛他定滴眼液治疗,对照组(50例)给予奥洛他定联合氟米龙滴眼液治疗。对两组患儿于治疗1周前后进行症状和体征的评分,随访3周后的疗效。结果治疗1周后,观察组的症状和体征评分明显低于对照组,有统计学差异(P<0.05);3周后随访,观察组有效率94.6%,对照组有效率92.0%,两组的疗效对比无统计学差异(χ^2=0.71,P=0.70)。结论超声雾化联合奥洛他定治疗儿童过敏结膜炎安全有效,尤其适用于单纯使用抗过敏眼药效果不佳,反复发作、用药依从性差的儿童过敏性结膜炎,适合临床推广应用。

Objective To observe the clinical effect of ultrasonic atomization combined with olopatadine for treating allergic conjunctivitis in children.Methods All 106 cases(212 eyes)of children with allergic conjunctivitis who were treated in Beijing Jingdu Children’s Hospital from March 2017 to December 2019,were enrolled and randomly divided into two groups matching gender and qge.The observation group(56 cases)were treated with ultrasonic atomization combined with olopatadine eye drops in a week,and the control group(50 cases)were treated with olopatadine and fluoromethane eye drops at the same period.The scores of symptoms and signs of the two groups were recorded before and after treatment.The efficacy was compared between the two groups after 3 weeks of follow-up.Results After 1 week of treatment,the scores of symptoms and signs in the observation group were significantly lower than those in the control group(P<0.05).After 3 weeks of follow-up,the total efficiency was 94.6%in the observation group and 92.0%in the control group.There was no statistically significant difference between the two groups(χ^2=0.71,P=0.70).Conclusion Ultrasonic atomization combined with olopatadine eye drops was safe and effective in the treatment of allergic conjunctivitis in children.The patients with poor efficacy,repeated attacks and poor medication compliance,are content with the treatment.