胺碘酮联合美托洛尔治疗冠心病心律失常的效果

Effect of Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease

目的探讨胺碘酮联合美托洛尔治疗冠心病心律失常的效果。方法选取2018年1月~2019年12月我院收治的100例冠心病心律失常患者作为研究对象,按照随机信封方法分为对照组(50例)与实验组(50例)。对照组采用胺碘酮治疗,实验组采用胺碘酮联合美托洛尔治疗。比较两组的血压、期前收缩情况、临床治疗总有效情况。结果两组治疗前的血压变化、期前收缩情况比较,差异无统计学意义(P>0.05);两组治疗后的收缩压、舒张压低于本组治疗前,差异有统计学意义(P<0.05);实验组治疗后的收缩压、舒张压低于对照组,差异有统计学意义(P<0.05);实验组治疗后的室性期前收缩数、房性期前收缩数低于对照组,差异有统计学意义(P<0.05);实验组的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论对冠心病心律失常患者采用胺碘酮合美托洛尔治疗能够改善血压变化,降低室性期前收缩及房性期前收缩发生率,提高临床治疗总有效率。

Objective To investigate the effect of Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease.Methods A total of 100 patients with arrhythmia of coronary heart disease admitted to our hospital from January 2018 to December 2019 were selected as the study objects.According to the random envelope method,they were divided into the control group(50 cases)and the experimental group(50 cases).The control group was treated with Amiodarone,and the experimental group was treated with Amiodarone and Metoprolol.The blood pressure,premature contraction and the total effective rate of clinical treatment were compared between the two groups.Results There were no significant differences between the two groups in blood pressure changes and premature contractions before treatment(P>0.05).The systolic blood pressure and diastolic blood pressure after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the systolic and diastolic blood pressure in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).The number of ventricular premature contraction and atrial premature contraction in the experimental group were less than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease can improve blood pressure,reduce the incidence of ventricular premature beats and atrial premature beats,and promote the total effective rate of clinical treatment.