度洛西汀与艾司西酞普兰治疗女性抑郁症的疗效观察

Efficacy of duloxetine and escitalopram in the treatment of female depression

目的:分析女性抑郁症患者使用度洛西汀与艾司西酞普兰的临床疗效。方法:选取2017年3月至2018年2月本院收治的女性抑郁症患者76例,按治疗方式不同将其中38例纳入度洛西汀组(采用度洛西汀进行治疗),剩余38例纳入艾司西酞普兰组(采用艾司西酞普兰进行治疗),比较两组治疗效果。结果:治疗后患者心理评分均明显下降,但两组比较无统计学差异(P>0.05);度洛西汀组患者总有效率为94.73%,艾司西酞普兰组为89.47%(P>0.05);度洛西汀组患者不良反应发生率为55.26%,艾司西酞普兰组为60.53%,差异无统计学意义(P>0.05)。结论:度洛西汀与艾司西酞普兰治疗女性抑郁症效果显著,不良反应较少,可有效提高临床疗效,安全性高。

Objective:To analyze the clinical efficacy of duloxetine and escitalopram in female patients with depression.Methods:76 female patients with depression admitted to our hospital from March 2017 to February 2018 were selected.According to different treatment methods,38 cases were included in duloxetine group(treated with duloxetine),and the remaining 38 cases were included in escitalopram group(treated with escitalopram),and the therapeutic effects of the two groups were compared.Results:After treatment,the psychological scores of patients were significantly decreased,but there was no significant difference between the two groups(P>0.05);the total effective rate of duloxetine group was 94.73%,and the escitalopram group was 89.47%(P>0.05);the incidence of adverse reactions in duloxetine group was 55.26%,and the escitalopram group was 60.53%,with no significant difference(P>0.05).Conclusion:Duloxetine and escitalopram are effective in the treatment of female depression with less adverse reactions,which can effectively improve the clinical efficacy and have high safety.