隔药灸神阙八阵穴对术后粘连性肠梗阻患者疗效及炎性反应因子的影响

Effects of Medicine-separated Moxibustion at Shenquebazhen on the Therapeutic Effects and Inflammatory Factor in the Patients of Postoperative Adhesive Intestinal Obstruction

目的:探讨隔药灸神阙八阵穴对术后粘连性肠梗阻(AIO)患者疗效及血清白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平的影响。方法:选取2013年1月至2017年4月唐山市人民医院收治的行腹腔手术患者280例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组140例,对照组采用常规治疗;观察组在对照组基础上给予隔药灸神阙八阵穴,均治疗1周。比较2组患者临床疗效、治疗后肠功能评分、治疗前后胃动素(MOT)水平、IL-6、TNF-α水平。结果:观察组总有效率为91.43%,显著高于对照组77.14%(P<0.05);治疗后,观察组恢复排气时间、腹部症状缓解时间、肠鸣音恢复时间均短于对照组(P<0.05)、2组患者MOT水平均低于治疗前,且观察组的MOT水平低于对照组(P<0.05)、2组患者的血清IL-6、TNF-α水平均显著低于治疗前,且观察组的血清IL-6、TNF-α水平均低于对照组(P<0.05)。结论:隔药灸神阙八阵穴治疗AIO疗效显著,能改善患者胃肠功能,降低MOT水平,有效调节血清IL-6、TNF-α水平。

Objective:To explore the effects of medicine-separated moxibustion at Shenque bazhen points on the efficacy of postoperative adhesive intestinal obstruction(AIO)patients and serum interleukin-6(IL-6)and tumor necrosis factor(TNF-α)levels.Methods:A total of 280 patients who underwent abdominal surgery in Tangshan City People′s Hospital between January 2013 and April 2017 were selected as the research objects and were divided into a control group(140 cases)and an observation group(140 cases)by random number table method.The control group was treated with conventional treatment and the observation group was given medicine-separated moxibustion at Shenquebazhen points on the basis of the control group.Both groups were treated for 1 week.The clinical efficacy,post-treatment intestinal function score,motilin level before and after treatment,and IL-6 and TNF-αlevels before and after treatment were observed and compared between the 2 groups.Results:The total effective rate in the observation group was 91.43%,which was significantly higher than that of the control group(77.14%(P<0.05));after treatment,the recovery time of the exhaust qi,the relief time of abdominal symptoms,and the recovery time of bowel sounds in the observation group were shorter than those in the control group(P<0.05).The MOT level of the 2 groups of patients was lower than that before treatment,and the MOT level of the observation group was lower than that of the control group(P<0.05).The serum IL-6 and TNF-αlevels of the 2 groups of patients were significantly lower than those before treatment.The levels of serum IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).Conclusion:The treatment of AIO with medicine-separated moxibustion at Shenquebazhen points has significant curative effects.It can improve gastrointestinal function,reduce the level of MOT,and effectively regulate the levels of serum IL-6 and TNF-α.