大气PM2.5及高脂饮食对哮喘发病影响的研究进展

Research Progress on the Effects of Atmospheric PM2.5 and High-Fat Diet on the Incidence of Asthma

大气PM2.5暴露与呼吸系统疾病密切相关,高脂饮食是哮喘的诱因之一.近年来,哮喘发病率在我国呈上升趋势.对大气PM2.5、高脂饮食及二者协同作用对哮喘发病的影响进行探讨,为哮喘的干预和治疗提供新思路.总结了PM2.5暴露与高脂饮食对哮喘的影响以及哮喘的发病机制:①颗粒物暴露可引发机体炎症反应,增加哮喘发病风险;②高脂饮食可通过代谢活化机体内免疫相关信号通路,导致炎症发生;③二者均会通过MyD88/TLRs信号通路和Th1/Th2机制对哮喘炎症产生影响.研究显示,PM2.5与高脂饮食对哮喘的作用机制具有一致性,二者对人群的健康影响可能具有协同作用.

Atmospheric PM2.5 exposure is associated with respiratory diseases,and a high-fat diet is also one of the triggers of asthma.In recent years,the prevalence of asthma has been on the rise in China.Discussion on the effects of atmospheric PM2.5,high-fat diet,and their synergistic effects on the prevalence of asthma may provide a new ideas for the interventional treatment of asthma.The present study summarized the effects of PM2.5 exposure and high-fat diet on asthma and the pathogenesis of asthma,and pointed out:(1)The particulate matter exposure can trigger the inflammatory response in the body and increase the risk of asthma.(2)A high-fat diet can cause inflammation through metabolic activation of immune-related signaling pathways in the body.(3)Both can affect asthma inflammation through the MyD88/ TLRs signaling pathway and Th1 /Th2.The study reveals:the mechanism of action of PM2.5 and high-fat diet on asthma is consistent,which may have a synergistic effect on human health.