利用公共数据库探索UBE2C在肝细胞癌中的表达及意义

Expression and significance of UBE2C in hepatocellular carcinoma based on public database

目的探讨泛素偶联酶2C(UBE2C)在肝细胞癌组织中的表达及临床意义。方法整合目前公共数据库和公共网站资源,深入探讨分析并验证UBE2C在肝细胞癌组织中的异常表达及临床病理、预后相关性,探索肝细胞癌预后的独立影响因素。结果在肝细胞癌组织中UBE2C无论在mRNA水平还是蛋白质水平,均呈现显著高表达;随着病理分期增高,UBE2C表达显著增高;在2个独立队列中,UBE2C高表达组肝细胞癌患者预后均显著优于低表达组患者;Cox单因素及多因素分析结果提示,病理分期和UBE2C是肝细胞癌的独立预后影响因素。结论UBE2C在肝细胞癌组织中显著高表达,且与肝细胞癌患者不良预后密切相关,是肝细胞癌患者的预后独立影响因素,未来其抑制剂可能在肝细胞癌的临床治疗中发挥重要作用。

Objective To investigate the expression and clinical significance of UBE2C in hepatocellular carcinoma tissues.Methods The current public database and public website resources were integrated,and the abnormal expression of UBE2C in hepatocellular carcinoma tumor tissues was analyzed and verified in depth,and its correlation with clinicopathology and prognosis was explored.Independent factors affecting prognosis of hepatocellular carcinoma were explored.Results The expression of UBE2C in hepatocellular carcinoma tumor tissues was significantly high,both at the mRNA level and at the protein level.As the pathological stage increased,the expression of UBE2C increased significantly.In two independent cohorts,the prognosis of patients with hepatocellular carcinoma in the UBE2C high expression group both were significantly better than those in the low-expression group;Cox univariate and multivariate analysis results suggested that pathological stage and UBE2C were independent prognostic factors of hepatocellular carcinoma.Conclusion UBE2C is significantly overexpressed in hepatocellular carcinoma tumor tissues,and is closely related to the poor prognosis of patients with hepatocellular carcinoma.It is an independent influencing factor for patients with hepatocellular carcinoma.Its inhibitor may play an important role in the clinical treatment of hepatocellular carcinoma in the future.