理胃疏志汤治疗慢性胃炎伴情感障碍的临床疗效及对炎症细胞浸润程度的影响

Clinical efficacy of Liwei Shuzhi deloction on chronic gastritis complicated with emotional disorder and its influence on the infiltration of inflammatory cells

目的观察理胃疏志汤治疗慢性胃炎伴情感障碍患者临床疗效及对炎症细胞浸润程度的影响。方法将80例慢性胃炎伴情感障碍患者按照随机数字表法分为2组。对照组40例予常规西药治疗,治疗组40例在对照组治疗基础上予理胃疏志汤治疗。2组均治疗4周,并于治疗结束后1、3个月进行随访。比较2组治疗前后中医症状评分,治疗前后及治疗后1、3个月血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分,治疗前后及治疗后3个月单核细胞、中性粒细胞浸润程度,并统计临床疗效。结果治疗组总有效率95.0%(38/40),对照组总有效率77.5%(31/40),治疗组疗效优于对照组(P<0.05)。治疗后2组各中医症状评分及总分均较本组治疗前降低(P<0.05),且治疗组治疗后各中医症状评分及总分均低于对照组(P<0.05)。治疗后及治疗后1、3个月,2组SOD水平均较本组治疗前升高(P<0.05),MDA水平均降低(P<0.05),且治疗后及治疗后1、3个月治疗组SOD水平均高于对照组同期(P<0.05),MDA水平均低于对照组同期(P<0.05)。治疗后及治疗后1、3个月,2组SAS、SDS评分均较本组治疗前降低(P<0.05),且治疗后及治疗后1、3个月治疗组SAS、SDS评分均低于对照组同期(P<0.05)。治疗后及治疗后3个月,2组单核细胞、中性粒细胞浸润程度评分均较本组治疗前下降(P<0.05),且治疗后及治疗后3个月治疗组单核细胞、中性粒细胞浸润程度评分均低于对照组同期(P<0.05)。结论理胃疏志汤能有效改善慢性胃炎患者临床症状、机体炎性反应和焦虑、抑郁状态,促进患者康复。

Objective To observe the clinical efficacy of Liwei Shuzhi deloction in treating chronic gastritis complicated with emotional disorder and its influence on the infiltration of inflammatory cells.Methods 80 patients with chronic gastritis complicated with affective disorder were randomly divided into two groups according to the random number table method.40 patients in the control group were treated by conventional western medicine.40 patients in the treatment group were treated by Liwei Shuzhi deloction on the basis of the control group.The patients in both the treatment group and control were treated for 4 weeks and followed up in 1 and 3 months after treatment.The traditional Chinese medicine(TCM)-based symptom scores before and after treatment,level of serum superoxide dismutase(SOD),malondialdehyde(MDA),self-rating anxiety scale(SAS)and self-rating depression scale(SDS)before and after treatment.The infiltration severity of monocytes and neutrophils before and after treatment and 3 months after treatment of two groups were compared,and clinical efficacies were statistically analyzed.Results The total effective rate of the treatment group was 95.0%(38/40)and that of the control group was 77.5%(31/40).The curative effect of the treatment group was better than that of the control group(P<0.05).The TCM-based symptom scores and total scores of two groups after treatment were lowered when compared to those indexes in the group before treatment(P<0.05),and TCM-based symptom scores and total scores of the treatment group after treatment were lower than those indexes of the control group(P<0.05).The SOD levels of patients in both groups after treatment and in 1 and 3 months after treatment were higher than those indexes before treatment during corresponding period(P<0.05),and MDA level lowered(P<0.05).SOD level of the treatment group after treatment and in 1 and 3 months after treatment was higher than such level of control group during corresponding period(P<0.05),and MDA level were lower than that of the control group during corresponding period(P<0.05).SAS and SDS scores of two groups after treatment and in 1 and 3 months after treatment were lower than those before treatment(P<0.05),and SAS and SDS scores of the treatment group after treatment and in 1 and 3 months after treatment were lower than those indexes of control group during corresponding period(P<0.05),the scores of monocyte and neutrephil infiltration of patients in two groups after treatment and in 3 months after treatment lowered when compared to those indexes before treatment(P<0.05),and the scores of monocyte and neutrophil infiltration of patients in the treatment group after treatment and in 3 months after treatment were lower than those indexes of patients in the control group during the corresponding period(P<0.05).Conclusion Liwei Shuzhi deloction can effectively improve the clinical symptoms,inflammatory reaction,anxiety and depression of patients with chronic gastritis,and promote the recovery of patients.